PMID- 25016712
OWN - NLM
STAT- MEDLINE
DCOM- 20140812
LR  - 20191112
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 60
IP  - 6
DP  - 2014
TI  - A case of dispermic chimerism with normal phenotype identified during ABO blood 
      grouping.
PG  - 1049-54
AB  - BACKGROUND: Human chimerism with normal phenotype derived from the fusion of two 
      different zygotes is a rare phenomenon. We describe a case of a phenotypically 
      normal 17-year-old diagnosed with dispermic chimerism during routine ABO blood 
      grouping. METHODS: ABO grouping, ABO genotyping, karyotyping, human leukocyte 
      antigen (HLA) typing, and short tandem repeat (STR) analysis were performed. 
      RESULTS: Forward typing with anti-A and anti-B sera resulted in mixed-field 
      agglutination of red blood cells. The mother and father were blood group O and 
      AB, respectively. The proposita had O1, A201 and B alleles in the ABO locus; O1 
      was a maternal allele, while A201 and B were the paternal alleles. The proposita 
      karyotype was 46,XX/46,XY. HLA typing revealed that the proposita had three 
      alleles (46, 51, 54) at the HLA-B locus, with the additional allele of paternal 
      origin. STR analysis identified three alleles for five of the 15 markers 
      (D2S1338, TPOX, D8S1179, D19S433, and D21S11) analyzed in the proposita's blood- 
      and skin fibroblast-derived DNA. The additional alleles of TPOX, D8S1179, and 
      D21S11 were of paternal origin. CONCLUSIONS: The genetic findings suggest that 
      this proposita was produced by dispermic fertilization of two identical haploid 
      ova formed by parthenogenetic activation.
FAU - Zhu, Pei-Yuan
AU  - Zhu PY
FAU - Yan, Jing-Mei
AU  - Yan JM
FAU - Xue, Min
AU  - Xue M
FAU - Ye, Dong
AU  - Ye D
FAU - Yao, Gen-Hong
AU  - Yao GH
FAU - Luan, Jian-Feng
AU  - Luan JF
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (ABO Blood-Group System)
SB  - IM
MH  - ABO Blood-Group System/*blood
MH  - Adolescent
MH  - *Blood Grouping and Crossmatching
MH  - Chimera/*blood
MH  - Female
MH  - Humans
MH  - Microsatellite Repeats
MH  - Phenotype
EDAT- 2014/07/16 06:00
MHDA- 2014/08/13 06:00
CRDT- 2014/07/15 06:00
PHST- 2014/07/15 06:00 [entrez]
PHST- 2014/07/16 06:00 [pubmed]
PHST- 2014/08/13 06:00 [medline]
AID - 10.7754/clin.lab.2013.130401 [doi]
PST - ppublish
SO  - Clin Lab. 2014;60(6):1049-54. doi: 10.7754/clin.lab.2013.130401.