PMID- 25017374
OWN - NLM
STAT- MEDLINE
DCOM- 20150723
LR  - 20151119
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 155
IP  - 2
DP  - 2014 Sep 11
TI  - Effects of Tulbaghia violacea Harv. (Alliaceae) rhizome methanolic extract on 
      kidney function and morphology in Dahl salt-sensitive rats.
PG  - 1194-203
LID - S0378-8741(14)00507-8 [pii]
LID - 10.1016/j.jep.2014.07.003 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Tulbaghia violacea has been used traditionally 
      for the treatment of several ailments, including hypertension. The herb has been 
      shown to have antihypertensive properties which have been attributed to its 
      angiotensin-converting enzymeinhibitory (ACEI) activity. It could, therefore, 
      prove beneficial in ameliorating renal pathology associated with hypertension. To 
      evaluate the effects of long-term administration of Tulbaghia violacea on renal 
      function and morphology in the Dahl salt-sensitive (DSS) rat model. MATERIALS AND 
      METHODS: Male DSS rats were treated intra-peritoneally (i.p.) as follows: 
      methanolic extract of Tulbaghia violacea: (TVL) (50 mg/kg/b.w.), captopril: (CAP) 
      (25 mg/kg/b.w.), or distilled water, control: (CON) (3 ml/kg/b.w.). Blood 
      pressure (BP) was measured bi-weekly, whilst 24-h urine volumes and electrolyte 
      concentrations were assessed weekly. Animals were sacrificed on day 49 by 
      halothane overdose. Blood was removed for determination of plasma and serum 
      electrolytes. Left kidney tissues were harvested for the determination of nuclear 
      factor-kappabeta (NF-kbeta) and transforming growth factor-beta (TGF-beta) gene expressions. 
      RESULTS: TVL significantly reduced mean arterial pressure (MAP) and diastolic 
      blood pressure (DBP). TVL showed reduced blood urea nitrogen, serum creatinine, 
      total protein in urine as well as increased serum total protein. TVL decreased 
      thiobarbituric acid reactive substances (TBARS) and increased glutathione 
      peroxidase (GPx) and superoxide dismutase (SOD) activity and nitric oxide 
      significantly. NF-kbeta and TGF-beta) gene expressions were significantly reduced in 
      TVL and CAP treated rats. Moreover, renal morphology improved significantly in 
      TVL and CAP treated animals. CONCLUSION: TVL and CAP demonstrated marked 
      improvement in renal function and morphology.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Moodley, Kogi
AU  - Moodley K
AD  - Department of Human Physiology, School of Basic Medical Sciences, Faculty of 
      Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, 
      South Africa.
FAU - Naidoo, Yougasphree
AU  - Naidoo Y
AD  - Department of Biology, School of Biological and Conservation Sciences, Faculty of 
      Science and Agriculture, University of KwaZulu-Natal, Private Bag X54001, Durban 
      4000, South Africa.
FAU - Mackraj, Irene
AU  - Mackraj I
AD  - Department of Human Physiology, School of Basic Medical Sciences, Faculty of 
      Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, 
      South Africa. Electronic address: mackraji@ukzn.ac.za.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140711
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Biomarkers)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Extracts)
RN  - 0 (Solvents)
RN  - 0 (Transforming Growth Factor beta)
RN  - AYI8EX34EU (Creatinine)
RN  - Y4S76JWI15 (Methanol)
SB  - IM
MH  - *Allium/chemistry
MH  - Animals
MH  - Antihypertensive Agents/administration & dosage/chemistry/isolation & 
      purification/*pharmacology
MH  - Arterial Pressure/drug effects
MH  - Biomarkers/blood/urine
MH  - Blood Urea Nitrogen
MH  - Creatinine/blood
MH  - Disease Models, Animal
MH  - Gene Expression Regulation
MH  - Hypertension/blood/*drug therapy/pathology/physiopathology/urine
MH  - Injections, Intraperitoneal
MH  - Kidney/*drug effects/metabolism/pathology/physiopathology
MH  - Male
MH  - Methanol/*chemistry
MH  - NF-kappa B/genetics/metabolism
MH  - Oxidative Stress/drug effects
MH  - Phytotherapy
MH  - Plant Extracts/administration & dosage/chemistry/isolation & 
      purification/*pharmacology
MH  - Plants, Medicinal
MH  - Proteinuria/physiopathology/prevention & control
MH  - Rats, Inbred Dahl
MH  - Rhizome
MH  - Solvents/metabolism
MH  - Time Factors
MH  - Transforming Growth Factor beta/genetics/metabolism
MH  - Urodynamics/drug effects
OTO - NOTNLM
OT  - DSS rats
OT  - Kidney function
OT  - Renoprotection
OT  - Tulbaghia violacea
EDAT- 2014/07/16 06:00
MHDA- 2015/07/24 06:00
CRDT- 2014/07/15 06:00
PHST- 2014/01/23 00:00 [received]
PHST- 2014/06/12 00:00 [revised]
PHST- 2014/07/01 00:00 [accepted]
PHST- 2014/07/15 06:00 [entrez]
PHST- 2014/07/16 06:00 [pubmed]
PHST- 2015/07/24 06:00 [medline]
AID - S0378-8741(14)00507-8 [pii]
AID - 10.1016/j.jep.2014.07.003 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2014 Sep 11;155(2):1194-203. doi: 10.1016/j.jep.2014.07.003. 
      Epub 2014 Jul 11.