PMID- 25019278
OWN - NLM
STAT- MEDLINE
DCOM- 20150910
LR  - 20220409
IS  - 1563-5244 (Electronic)
IS  - 0883-0185 (Linking)
VI  - 34
IP  - 1
DP  - 2015 Jan
TI  - mTOR signaling in T cell immunity and autoimmunity.
PG  - 50-66
LID - 10.3109/08830185.2014.933957 [doi]
AB  - The mammalian target of rapamycin (mTOR), a phosphoinositide-3-kinase-related 
      protein kinase, acts as a rheostat capable of integrating a variety of 
      environmental cues in the form of nutrients, energy, and growth factors to 
      modulate organismal processes and homeostasis. Recently, there is a growing 
      appreciation of mTOR in adaptive immunity for its crucial roles in keeping a 
      proper balance between T cell quiescence and activation. Under steady-state 
      circumstances, mTOR is subtly inhibited by multiple mechanisms to maintain normal 
      T cell homeostasis. Antigen recognition by naive T cells leads to mTOR 
      activation, which subsequently promotes the differentiation of these cells into 
      distinct effector T cell subsets. This review focuses primarily on the recent 
      literature with respect to the regulatory effects and mechanisms of mTOR 
      signaling in dictating T cell fate, and discusses the therapeutic implications of 
      mTOR modulation in T-cell-mediated autoimmunity.
FAU - Liu, Yu
AU  - Liu Y
AD  - 1School of Chemistry and Pharmaceutical Engineering, Qilu University of 
      Technology, Jinan, P. R. China.
FAU - Zhang, Da-tong
AU  - Zhang DT
FAU - Liu, Xin-guang
AU  - Liu XG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140714
PL  - England
TA  - Int Rev Immunol
JT  - International reviews of immunology
JID - 8712260
RN  - 0 (Cytokines)
RN  - 0 (Immunologic Factors)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - *Adaptive Immunity
MH  - Autoimmune Diseases/drug therapy/genetics/*metabolism/pathology
MH  - *Autoimmunity
MH  - Cell Differentiation
MH  - Cytokines/genetics/immunology
MH  - Energy Metabolism/immunology
MH  - Gene Expression Regulation
MH  - Homeostasis
MH  - Humans
MH  - Immunity, Innate
MH  - Immunologic Factors/therapeutic use
MH  - Lymphocyte Activation
MH  - Signal Transduction
MH  - T-Lymphocyte Subsets/cytology/immunology/*metabolism
MH  - T-Lymphocytes/cytology/immunology/*metabolism
MH  - TOR Serine-Threonine Kinases/genetics/*immunology
OTO - NOTNLM
OT  - T cell immunity
OT  - autoimmunity
OT  - mTOR
EDAT- 2014/07/16 06:00
MHDA- 2015/09/12 06:00
CRDT- 2014/07/15 06:00
PHST- 2014/07/15 06:00 [entrez]
PHST- 2014/07/16 06:00 [pubmed]
PHST- 2015/09/12 06:00 [medline]
AID - 10.3109/08830185.2014.933957 [doi]
PST - ppublish
SO  - Int Rev Immunol. 2015 Jan;34(1):50-66. doi: 10.3109/08830185.2014.933957. Epub 
      2014 Jul 14.