PMID- 25023083
OWN - NLM
STAT- MEDLINE
DCOM- 20150831
LR  - 20140811
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 57
DP  - 2014 Oct
TI  - Depressive symptoms and cognitive performance in older adults.
PG  - 149-56
LID - S0022-3956(14)00172-1 [pii]
LID - 10.1016/j.jpsychires.2014.06.004 [doi]
AB  - Many longitudinal studies have found that older adults with depressive symptoms 
      or depression have increased risk of cognitive impairment. We investigated the 
      relationships between depressive symptoms or depression, cognitive function, 
      serum brain-derived neurotrophic factor (BDNF), and volumetric MRI measurements 
      in older adults. A total of 4352 individuals aged 65 years or older (mean age 72 
      years) participated in the study. We investigated medical history and geriatric 
      depression scale-15 (GDS-15) items to determine depression and depressive 
      symptoms. Cognitive tests included the mini-mental state examination (MMSE), 
      story memory, word list memory, trail-making tests, and the symbol digit 
      substitution task. Of the 4352 participants, 570 (13%) fulfilled the criteria for 
      depressive symptoms (GDS-15: 6 + points) and 87 (2%) were diagnosed with 
      depression. All cognitive tests showed significant differences between the 'no 
      depressive symptoms', 'depressive symptoms', and 'depression' groups. The 
      'depressive symptoms' and 'depression' groups showed lower serum BDNF (p < 0.001) 
      concentrations than the 'no depressive symptoms' group. The 'depressive symptoms' 
      group exhibited greater atrophy of the right medial temporal lobe than did the 
      'no depressive symptoms' group (p = 0.023). These results suggest that memory, 
      executive function, and processing speed examinations are useful to identify 
      cognitive decline in older adults who have depressive symptoms and depression. 
      Serum BDNF concentration and atrophy of the right medial temporal lobe may in 
      part mediate the relationships between depressive symptoms and cognitive decline.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Shimada, Hiroyuki
AU  - Shimada H
AD  - Department of Functioning Activation, Center for Gerontology and Social Science, 
      National Center for Geriatrics and Gerontology, 35 Gengo, Morioka-machi, Obu, 
      Aichi 474-8511, Japan. Electronic address: shimada@ncgg.go.jp.
FAU - Park, Hyuntae
AU  - Park H
AD  - Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan.
FAU - Makizako, Hyuma
AU  - Makizako H
AD  - Department of Functioning Activation, Center for Gerontology and Social Science, 
      National Center for Geriatrics and Gerontology, 35 Gengo, Morioka-machi, Obu, 
      Aichi 474-8511, Japan.
FAU - Doi, Takehiko
AU  - Doi T
AD  - Department of Functioning Activation, Center for Gerontology and Social Science, 
      National Center for Geriatrics and Gerontology, 35 Gengo, Morioka-machi, Obu, 
      Aichi 474-8511, Japan.
FAU - Lee, Sangyoon
AU  - Lee S
AD  - Department of Functioning Activation, Center for Gerontology and Social Science, 
      National Center for Geriatrics and Gerontology, 35 Gengo, Morioka-machi, Obu, 
      Aichi 474-8511, Japan.
FAU - Suzuki, Takao
AU  - Suzuki T
AD  - Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140624
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/blood/pathology/*psychology
MH  - Atrophy
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - *Cognition
MH  - Depression/blood/diagnosis/pathology/*psychology
MH  - Depressive Disorder/blood/diagnosis/pathology/*psychology
MH  - Executive Function
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Memory
MH  - Neuropsychological Tests
MH  - Risk Factors
MH  - Temporal Lobe/pathology
OTO - NOTNLM
OT  - BDNF
OT  - Brain atrophy
OT  - Cognitive test
OT  - Elderly
OT  - Geriatric depression scale
OT  - Hippocampus
EDAT- 2014/07/16 06:00
MHDA- 2015/09/01 06:00
CRDT- 2014/07/16 06:00
PHST- 2014/01/02 00:00 [received]
PHST- 2014/05/21 00:00 [revised]
PHST- 2014/06/06 00:00 [accepted]
PHST- 2014/07/16 06:00 [entrez]
PHST- 2014/07/16 06:00 [pubmed]
PHST- 2015/09/01 06:00 [medline]
AID - S0022-3956(14)00172-1 [pii]
AID - 10.1016/j.jpsychires.2014.06.004 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2014 Oct;57:149-56. doi: 10.1016/j.jpsychires.2014.06.004. Epub 
      2014 Jun 24.