PMID- 25023134
OWN - NLM
STAT- MEDLINE
DCOM- 20150915
LR  - 20211021
IS  - 1868-601X (Electronic)
IS  - 1868-4483 (Linking)
VI  - 6
IP  - 1
DP  - 2015 Feb
TI  - The effects of poststroke aerobic exercise on neuroplasticity: a systematic 
      review of animal and clinical studies.
PG  - 13-28
LID - 10.1007/s12975-014-0357-7 [doi]
AB  - Aerobic exercise may be a catalyst to promote neuroplasticity and recovery 
      following stroke; however, the optimal methods to measure neuroplasticity and the 
      effects of training parameters have not been fully elucidated. We conducted a 
      systematic review and synthesis of clinical trials and studies in animal models 
      to determine (1) the extent to which aerobic exercise influences poststroke 
      markers of neuroplasticity, (2) the optimal parameters of exercise required to 
      induce beneficial effects, and (3) consistent outcomes in animal models that 
      could help inform the design of future trials. Synthesized findings show that 
      forced exercise at moderate to high intensity increases brain-derived 
      neurotrophic factor (BDNF), insulin-like growth factor-I (IGF-I), nerve growth 
      factor (NGF), and synaptogenesis in multiple brain regions. Dendritic branching 
      was most responsive to moderate rather than intense training. Disparity between 
      clinical stroke and stroke models (timing of initiation of exercise, age, gender) 
      and clinically viable methods to measure neuroplasticity are some of the areas 
      that should be addressed in future research.
FAU - Ploughman, Michelle
AU  - Ploughman M
AD  - Recovery and Performance Laboratory, Rehabilitation Research Unit, Faculty of 
      Medicine, Memorial University, Rm 400, L.A. Miller Centre, 100 Forest Rd., St. 
      John's, NL, Canada, michelle.ploughman@med.mun.ca.
FAU - Austin, Mark W
AU  - Austin MW
FAU - Glynn, Lindsay
AU  - Glynn L
FAU - Corbett, Dale
AU  - Corbett D
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20140715
PL  - United States
TA  - Transl Stroke Res
JT  - Translational stroke research
JID - 101517297
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Aged
MH  - Animals
MH  - Brain/metabolism/*physiopathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Clinical Trials as Topic
MH  - Dendrites/physiology
MH  - *Exercise Therapy
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factor/metabolism
MH  - *Neuronal Plasticity
MH  - Recovery of Function
MH  - Stroke/*physiopathology
MH  - *Stroke Rehabilitation
MH  - Synapses/physiology
EDAT- 2014/07/16 06:00
MHDA- 2015/09/16 06:00
CRDT- 2014/07/16 06:00
PHST- 2014/04/16 00:00 [received]
PHST- 2014/06/30 00:00 [accepted]
PHST- 2014/06/02 00:00 [revised]
PHST- 2014/07/16 06:00 [entrez]
PHST- 2014/07/16 06:00 [pubmed]
PHST- 2015/09/16 06:00 [medline]
AID - 10.1007/s12975-014-0357-7 [doi]
PST - ppublish
SO  - Transl Stroke Res. 2015 Feb;6(1):13-28. doi: 10.1007/s12975-014-0357-7. Epub 2014 
      Jul 15.