PMID- 25023521
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141218
LR  - 20220321
IS  - 1869-6953 (Print)
IS  - 1869-6961 (Electronic)
IS  - 1869-6961 (Linking)
VI  - 5
IP  - 2
DP  - 2014 Dec
TI  - Increased Risk of Severe Hypoglycemic Events with Increasing Frequency of 
      Non-severe Hypoglycemic Events in Patients with Type 1 and Type 2 Diabetes.
PG  - 447-58
LID - 10.1007/s13300-014-0075-x [doi]
AB  - INTRODUCTION: Severe hypoglycemic events (SHEs) are associated with significant 
      morbidity, mortality and costs. However, the more common non-severe hypoglycemic 
      events (NSHEs) are less well explored. We investigated the association between 
      reported frequency of NSHEs and SHEs among patients with type 1 diabetes mellitus 
      (T1DM) and type 2 diabetes mellitus (T2DM) in the PREDICTIVE study. METHODS: 
      PREDICTIVE was a global, prospective, observational study. Patients with T1DM 
      (n = 7,420) or T2DM (n = 12,981), starting treatment with insulin detemir, 
      reported the number of NSHEs and SHEs experienced during the 4 weeks prior to 
      baseline and follow-up visits (mean 14.4 weeks). Logistic regression was used to 
      determine the odds ratio (OR) of experiencing >/=1 SHE, in patients having 1-4 
      or >/=5 NSHEs, versus those having 0 NSHEs, while controlling for baseline 
      covariates. RESULTS: Hypoglycemia rates were lower at follow-up than baseline. At 
      baseline 59.2% (T1DM) and 18.8% (T2DM) reported any hypoglycemia and at follow-up 
      39.5% (T1DM) and 8.6% (T2DM). There was a significant (P < 0.0001) increase in 
      the odds of >/=1 SHEs with increasing frequency of NSHEs in T1DM and T2DM, for both 
      crude and adjusted estimates. At baseline, in T1DM, ORs for >/=1 SHE were 1.92 and 
      2.13 for 1-4 and >/=5 NSHEs, respectively; the corresponding ORs in T2DM were 10.83 
      and 15.36, respectively. At follow-up, the ORs for >/=1 SHE were 2.01 and 3.20 
      (T1DM) and 18.99 and 24.29 (T2DM) for 1-4 and >/=5 NSHEs, respectively. CONCLUSION: 
      A statistically significant association between NSHE and SHE frequency was found 
      in T1DM and T2DM. These data provide a clear rationale for the reduction of 
      hypoglycemic events, regardless of severity, while striving for optimal glycemic 
      control.
FAU - Sreenan, Seamus
AU  - Sreenan S
AD  - Department of Endocrinology, Connolly Hospital, Blanchardstown, Dublin 15, 
      Ireland.
FAU - Andersen, Marc
AU  - Andersen M
FAU - Thorsted, Brian Larsen
AU  - Thorsted BL
FAU - Wolden, Michael L
AU  - Wolden ML
FAU - Evans, Marc
AU  - Evans M
LA  - eng
PT  - Journal Article
DEP - 20140715
PL  - United States
TA  - Diabetes Ther
JT  - Diabetes therapy : research, treatment and education of diabetes and related 
      disorders
JID - 101539025
PMC - PMC4269646
EDAT- 2014/07/16 06:00
MHDA- 2014/07/16 06:01
PMCR- 2014/07/15
CRDT- 2014/07/16 06:00
PHST- 2014/05/08 00:00 [received]
PHST- 2014/07/16 06:00 [entrez]
PHST- 2014/07/16 06:00 [pubmed]
PHST- 2014/07/16 06:01 [medline]
PHST- 2014/07/15 00:00 [pmc-release]
AID - 75 [pii]
AID - 10.1007/s13300-014-0075-x [doi]
PST - ppublish
SO  - Diabetes Ther. 2014 Dec;5(2):447-58. doi: 10.1007/s13300-014-0075-x. Epub 2014 
      Jul 15.