PMID- 25023586
OWN - NLM
STAT- MEDLINE
DCOM- 20150618
LR  - 20141024
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 59
IP  - 5
DP  - 2014 Nov
TI  - Dilated intercellular spaces in eosinophilic esophagitis.
PG  - 589-93
LID - 10.1097/MPG.0000000000000491 [doi]
AB  - OBJECTIVES: Dilated intercellular spaces (DIS) in the esophageal epithelium can 
      be induced by acid and reduced by proton pump inhibitors (PPI), and are thus 
      considered a marker of gastroesophageal reflux disease (GERD). Over the years, 
      however, DIS have also been reported in esophagitis unrelated to GERD. Because 
      DIS have never been formally measured in eosinophilic esophagitis (EoE), we aimed 
      at detecting and measuring DIS in EoE before and after nutritional or 
      pharmacological therapy. METHODS: In 22 children with EoE, DIS were measured by 
      morphometry and transmission electron microscopy (TEM), before and after 
      treatment with topical steroids (n = 16) and/or exclusion diet (n = 13). A total 
      of 30 children undergoing upper gastrointestinal endoscopy with biopsy for 
      nonesophageal disorders acted as controls. RESULTS: In controls, the mean (+/- 
      standard deviation [SD]) number of esophageal eosinophils was 0.91 (+/- 0.47) and 
      the mean DIS values were 0.62 (+/- 0.08) mum at morphometry and 0.33 (+/- 0.24) mum at 
      TEM. In patients with EoE, the mean (+/- SD) number of esophageal eosinophils 
      decreased from 31.8 (+/- 6.96) to 6.64 (+/- 5.01) (P < 0.0001), and the mean DIS 
      values decreased from 2.26 (+/- 0.21) to 1.23 (+/- 0.20) mum at morphometry (P < 
      0.0001), and from 2.24 (+/- 0.28) to 0.98 (+/- 0.19) mum at TEM (P < 0.0001), 
      respectively, before and after treatment. CONCLUSIONS: DIS are a prominent 
      morphological feature of EoE, in which they can be significantly reduced by an 
      appropriate non-PPI therapy.
FAU - Ravelli, Alberto
AU  - Ravelli A
AD  - *Gastroenterology and GI Endoscopy Unit, University Department of Pediatrics, 
      Children's Hospital daggerDepartment of Pathology II, Spedali Civili, Brescia, Italy.
FAU - Villanacci, Vincenzo
AU  - Villanacci V
FAU - Cadei, Moris
AU  - Cadei M
FAU - Fuoti, Maurizio
AU  - Fuoti M
FAU - Gennati, Giada
AU  - Gennati G
FAU - Salemme, Marianna
AU  - Salemme M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Eosinophilic Esophagitis/*pathology
MH  - Eosinophils/*pathology
MH  - Esophagus/*pathology
MH  - *Extracellular Space
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Mucous Membrane/*pathology
EDAT- 2014/07/16 06:00
MHDA- 2015/06/19 06:00
CRDT- 2014/07/16 06:00
PHST- 2014/07/16 06:00 [entrez]
PHST- 2014/07/16 06:00 [pubmed]
PHST- 2015/06/19 06:00 [medline]
AID - 10.1097/MPG.0000000000000491 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2014 Nov;59(5):589-93. doi: 
      10.1097/MPG.0000000000000491.