PMID- 25023770 OWN - NLM STAT- MEDLINE DCOM- 20141201 LR - 20140715 IS - 1020-3397 (Print) IS - 1020-3397 (Linking) VI - 20 IP - 7 DP - 2014 Jul 8 TI - Childhood very severe pneumonia and meningitis-related hospitalization and death in Yemen, before and after introduction of H. influenzae type b (Hib) vaccine. PG - 431-41 AB - Haemophilus influenzae type b (Hib) vaccine was included in the Yemen immunization programme in 2005. This study compared the rates of very severe pneumonia and all-cause meningitis hospitalization and death, before and after introduction of conjugate Hib vaccine, and reports the results of the 2010 bacterial meningitis surveillance. A retrospective analysis was made of data collected for 2000-2010 for all children aged 2-60 months in the main children's hospital in Sana'a. Compared with the pre-Hib vaccination period, the post-Hib period showed significant and impressive reductions in the rates of hospitalization and death for all-cause meningitis. However, hospitalization and death for very severe pneumonia improved only modestly, and there was evidence of a decreasing but non-significant trend indicting that very severe pneumonia was a non-specific endpoint with multi-etiologies (both viral and bacterial). Very severe pneumonia remains the leading cause of severe morbidity and death for young children, particularly those aged < 12 months. FAU - Banajeh, S M AU - Banajeh SM AD - Department of Paediatrics and Child Health, University of Sana'a, Sana'a, Yemen. FAU - Ashoor, O AU - Ashoor O AD - Department of Paediatrics, Al-Sabeen Hospital for Women and Children, Sana'a, Yemen. FAU - Al-Magramy, A S AU - Al-Magramy AS AD - Department of Paediatrics, Al-Sabeen Hospital for Women and Children, Sana'a, Yemen. LA - eng PT - Journal Article PT - Observational Study DEP - 20140708 PL - Egypt TA - East Mediterr Health J JT - Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit JID - 9608387 RN - 0 (Haemophilus Vaccines) SB - IM MH - Child, Preschool MH - Female MH - Haemophilus Infections/*epidemiology/mortality/prevention & control MH - Haemophilus Vaccines/*administration & dosage MH - Haemophilus influenzae type b/*immunology MH - Hospitalization/statistics & numerical data MH - Humans MH - Immunization Programs MH - Infant MH - Male MH - Meningitis, Haemophilus/*epidemiology/mortality/prevention & control MH - Pneumonia, Bacterial/*epidemiology/microbiology/mortality/prevention & control MH - Retrospective Studies MH - Yemen/epidemiology EDAT- 2014/07/16 06:00 MHDA- 2014/12/15 06:00 CRDT- 2014/07/16 06:00 PHST- 2013/06/23 00:00 [received] PHST- 2014/01/14 00:00 [accepted] PHST- 2014/07/16 06:00 [entrez] PHST- 2014/07/16 06:00 [pubmed] PHST- 2014/12/15 06:00 [medline] PST - epublish SO - East Mediterr Health J. 2014 Jul 8;20(7):431-41.