PMID- 25023988
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20211021
IS  - 1460-2180 (Electronic)
IS  - 0143-3334 (Print)
IS  - 0143-3334 (Linking)
VI  - 35
IP  - 10
DP  - 2014 Oct
TI  - A low carbohydrate, high protein diet combined with celecoxib markedly reduces 
      metastasis.
PG  - 2291-9
LID - 10.1093/carcin/bgu147 [doi]
AB  - We recently demonstrated that both murine and human carcinomas grow significantly 
      slower in mice on low carbohydrate (CHO), high protein diets than on isocaloric 
      Western diets and that a further reduction in tumor growth rates occur when the 
      low CHO diets are combined with the cyclooxygenase-2 inhibitor, celecoxib. 
      Following upon these studies, we asked herein what effect low CHO, high protein 
      diets, with or without celecoxib, might have on tumor metastasis. In the highly 
      metastatic 4T1 mouse mammary tumor model, a 15% CHO, high protein diet 
      supplemented with celecoxib (1 g/kg chow) markedly reduced lung metastases. 
      Moreover, in longer-term studies using male Transgenic Adenocarcinoma of the 
      Mouse Prostate mice, which are predisposed to metastatic prostate cancer, the 15% 
      CHO diet, with and without celecoxib (0.3 g/kg chow), gave the lowest incidence 
      of metastases, but a more moderate 25% CHO diet containing celecoxib led to the 
      best survival. Metabolic studies with 4T1 tumors suggested that the low CHO, high 
      protein diets may be forcing tumors to become dependent on amino acid catabolism 
      for survival/growth. Taken together, our results suggest that a combination of a 
      low CHO, high protein diet with celecoxib substantially reduces metastasis.
CI  - (c) The Author 2014. Published by Oxford University Press. All rights reserved. For 
      Permissions, please email: journals.permissions@oup.com.
FAU - Ho, Victor W
AU  - Ho VW
AD  - The Terry Fox Laboratory and.
FAU - Hamilton, Melisa J
AU  - Hamilton MJ
AD  - The Terry Fox Laboratory and The Integrative Oncology Department, BC Cancer 
      Research Centre, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, 
      Canada.
FAU - Dang, Ngoc-Ha Thi
AU  - Dang NH
AD  - The Department of Biological Sciences and the Metabolomics Centre, University of 
      Calgary, Calgary, Alberta T2N 1N4, Canada and.
FAU - Hsu, Brian E
AU  - Hsu BE
AD  - The Terry Fox Laboratory and.
FAU - Adomat, Hans H
AU  - Adomat HH
AD  - The Vancouver Prostate Centre at Vancouver General Hospital, Vancouver, British 
      Columbia V6H 3Z6, Canada.
FAU - Guns, Emma S
AU  - Guns ES
AD  - The Vancouver Prostate Centre at Vancouver General Hospital, Vancouver, British 
      Columbia V6H 3Z6, Canada.
FAU - Weljie, Aalim
AU  - Weljie A
AD  - The Department of Biological Sciences and the Metabolomics Centre, University of 
      Calgary, Calgary, Alberta T2N 1N4, Canada and.
FAU - Samudio, Ismael
AU  - Samudio I
AD  - The Terry Fox Laboratory and.
FAU - Bennewith, Kevin L
AU  - Bennewith KL
AD  - The Department of Biological Sciences and the Metabolomics Centre, University of 
      Calgary, Calgary, Alberta T2N 1N4, Canada and.
FAU - Krystal, Gerald
AU  - Krystal G
AD  - The Terry Fox Laboratory and gkrystal@bccrc.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140714
PL  - England
TA  - Carcinogenesis
JT  - Carcinogenesis
JID - 8008055
RN  - 0 (Dietary Proteins)
RN  - 0 (Pyrazoles)
RN  - 0 (Sulfonamides)
RN  - JCX84Q7J1L (Celecoxib)
SB  - IM
MH  - Animals
MH  - Celecoxib
MH  - Diet Therapy/methods
MH  - *Diet, Carbohydrate-Restricted
MH  - Dietary Proteins/*pharmacology
MH  - Disease Models, Animal
MH  - Lung Neoplasms/diet therapy/drug therapy/secondary
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Neoplasm Metastasis/*drug therapy/therapy
MH  - Prostatic Neoplasms/diet therapy/drug therapy/metabolism/pathology
MH  - Pyrazoles/*pharmacology
MH  - Sulfonamides/*pharmacology
PMC - PMC4178469
EDAT- 2014/07/16 06:00
MHDA- 2015/05/12 06:00
PMCR- 2015/10/01
CRDT- 2014/07/16 06:00
PHST- 2014/07/16 06:00 [entrez]
PHST- 2014/07/16 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - bgu147 [pii]
AID - 10.1093/carcin/bgu147 [doi]
PST - ppublish
SO  - Carcinogenesis. 2014 Oct;35(10):2291-9. doi: 10.1093/carcin/bgu147. Epub 2014 Jul 
      14.