PMID- 25024335
OWN - NLM
STAT- MEDLINE
DCOM- 20150723
LR  - 20220409
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 42
IP  - 4
DP  - 2014
TI  - Cognitive dysfunctions in middle-aged type 2 diabetic patients and neuroimaging 
      correlations: a cross-sectional study.
PG  - 1337-46
LID - 10.3233/JAD-140702 [doi]
AB  - BACKGROUND/OBJECTIVE: The aim was to assess the neuropsychological performance of 
      a group of middle-aged patients with well-controlled type 2 diabetes mellitus 
      (T2DM) and to examine whether the neuropsychological deficits correlate with 
      structural and functional brain alterations. METHODS: We compared 25 subjects 
      with T2DM aged 45-65 years with 25 control participants matched for age, gender, 
      and educational level. The neuropsychological battery was designed to examine 
      executive functions, attention, information processing speed, and verbal memory. 
      Severity of depression was assessed using the Hamilton Depression Rating Scale 
      and cardiovascular risk factors were assessed using the Framingham Cardiovascular 
      Risk Profile Score. The presence of at least one APOEepsilon4 allele was determined. 
      Reduced gray matter density was analyzed using voxel-based morphometry and brain 
      glucose metabolic changes were assessed by 18FDG-PET. RESULTS: T2DM subjects had 
      significantly lower scores than subjects without T2DM in the Trail-making Test B 
      (p < 0.004), Color-Word Stroop test (p < 0.005), Semantic Fluency (p < 0.006), 
      Digit-Symbol modalities test (p < 0.02), Text Recall from the Wechsler Memory 
      Scale (p < 0.0001), Rey-Osterrieth Complex Figure-copy (p < 0.004), and delayed 
      reproduction (p < 0.03). Worse executive functions and memory functioning 
      correlated predominantly with less gray matter density and reduced glucose 
      metabolism in the orbital and prefrontal cortex, temporal (middle gyrus, 
      parahippocampus and uncus), and cerebellum regions (p < 0.001). CONCLUSIONS: T2DM 
      subjects presented cognitive dysfunctions compared with controls. 
      Clinical-neuroimaging correlations corresponded to brain changes (reduced gray 
      matter density and glucose metabolism) mainly in fronto-temporal areas.
FAU - Garcia-Casares, Natalia
AU  - Garcia-Casares N
AD  - Department of Medicine, Faculty of Medicine, University of Malaga, Malaga, Spain 
      Centro de Investigaciones Medico-Sanitarias (C.I.M.E.S), General Foundation 
      University of Malaga, Malaga, Spain.
FAU - Jorge, Ricardo E
AU  - Jorge RE
AD  - Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 
      Houston, TX, USA.
FAU - Garcia-Arnes, Juan A
AU  - Garcia-Arnes JA
AD  - Department of Endocrinology, Carlos Haya Hospital, Malaga, Spain.
FAU - Acion, Laura
AU  - Acion L
AD  - The Iowa Consortium for Substance Abuse Research and Evaluation, University of 
      Iowa, Iowa City, IA, USA.
FAU - Berthier, Marcelo L
AU  - Berthier ML
AD  - Department of Medicine, Faculty of Medicine, University of Malaga, Malaga, Spain 
      Centro de Investigaciones Medico-Sanitarias (C.I.M.E.S), General Foundation 
      University of Malaga, Malaga, Spain.
FAU - Gonzalez-Alegre, Pedro
AU  - Gonzalez-Alegre P
AD  - Department of Neurology, Carver College of Medicine, The University of Iowa, Iowa 
      City, IA, USA.
FAU - Nabrozidis, Alejandro
AU  - Nabrozidis A
AD  - Centro de Investigaciones Medico-Sanitarias (C.I.M.E.S), General Foundation 
      University of Malaga, Malaga, Spain.
FAU - Gutierrez, Antonio
AU  - Gutierrez A
AD  - Centro de Investigaciones Medico-Sanitarias (C.I.M.E.S), General Foundation 
      University of Malaga, Malaga, Spain.
FAU - Ariza, Maria Jose
AU  - Ariza MJ
AD  - Department of Medicine, Faculty of Medicine, University of Malaga, Malaga, Spain 
      Centro de Investigaciones Medico-Sanitarias (C.I.M.E.S), General Foundation 
      University of Malaga, Malaga, Spain.
FAU - Rioja, Jose
AU  - Rioja J
AD  - Department of Medicine, Faculty of Medicine, University of Malaga, Malaga, Spain 
      Centro de Investigaciones Medico-Sanitarias (C.I.M.E.S), General Foundation 
      University of Malaga, Malaga, Spain.
FAU - Gonzalez-Santos, Pedro
AU  - Gonzalez-Santos P
AD  - Department of Medicine, Faculty of Medicine, University of Malaga, Malaga, Spain 
      Centro de Investigaciones Medico-Sanitarias (C.I.M.E.S), General Foundation 
      University of Malaga, Malaga, Spain.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aged
MH  - Brain/diagnostic imaging/pathology/physiopathology
MH  - Cognition Disorders/diagnostic imaging/pathology/*physiopathology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/diagnostic 
      imaging/pathology/*physiopathology/psychology
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Glucose/metabolism
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Positron-Emission Tomography
MH  - Radiopharmaceuticals
OTO - NOTNLM
OT  - Cognition
OT  - dementia
OT  - magnetic resonance imaging
OT  - mild cognitive impairment
OT  - neuropsychology
OT  - positron emission tomography
OT  - type 2 diabetes mellitus
EDAT- 2014/07/16 06:00
MHDA- 2015/07/24 06:00
CRDT- 2014/07/16 06:00
PHST- 2014/07/16 06:00 [entrez]
PHST- 2014/07/16 06:00 [pubmed]
PHST- 2015/07/24 06:00 [medline]
AID - K583606626014N4N [pii]
AID - 10.3233/JAD-140702 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2014;42(4):1337-46. doi: 10.3233/JAD-140702.