PMID- 25024337
OWN - NLM
STAT- MEDLINE
DCOM- 20150723
LR  - 20211021
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Print)
IS  - 1387-2877 (Linking)
VI  - 42
IP  - 4
DP  - 2014
TI  - Apathy and APOE4 are associated with reduced BDNF levels in Alzheimer's disease.
PG  - 1347-55
LID - 10.3233/JAD-140849 [doi]
AB  - Reduced brain-derived neurotrophic factor (BDNF) signaling is considered as a 
      pathogenic event in early Alzheimer's disease (AD), but the influence of apathy 
      and apolipoprotein E epsilon4 allele (APOE4) on serum BDNF values was not previously 
      investigated in AD. We evaluated serum BDNF levels in AD, amnestic mild cognitive 
      impairment (MCI), and control subjects. Baseline BDNF levels were similar in AD, 
      MCI, and controls. AD patients having apathy showed lower BDNF values than 
      patients without apathy (p < 0.05). After correction for the influence of apathy, 
      APOE4 carriers showed lower BDNF levels (p < 0.01) and MMSE scores (p < 0.01) 
      than non-APOE4 carriers in the subgroup of AD females, but not in males. 
      Significant (p < 0.05) positive correlations between BDNF values and MMSE scores 
      were only observed in subgroups of AD males and of AD patients without apathy. 
      These results are showing the association of apathy and APOE4 with reduced serum 
      BDNF levels in AD, and are suggesting that BDNF reductions might contribute to 
      the worse cognitive performance exhibited by AD apathetic patients and female 
      APOE4 carriers.
FAU - Alvarez, Anton
AU  - Alvarez A
AD  - Medinova Institute of Neurosciences, Clinica RehaSalud, A Coruna, Spain.
FAU - Aleixandre, Manuel
AU  - Aleixandre M
AD  - School of Psychology, Granada University, Granada, Spain.
FAU - Linares, Carlos
AU  - Linares C
AD  - Complejo Asistencial HHSCJ, Malaga, Spain.
FAU - Masliah, Eliezer
AU  - Masliah E
AD  - Departments of Neurosciences and Pathology, University of California San Diego, 
      School of Medicine, La Jolla, CA, USA.
FAU - Moessler, Herbert
AU  - Moessler H
AD  - Ever NeuroPharma, Unterach, Austria.
LA  - eng
GR  - P50 AG005131/AG/NIA NIH HHS/United States
GR  - P30 NS076411/NS/NINDS NIH HHS/United States
GR  - R01 AG018440/AG/NIA NIH HHS/United States
GR  - P01 AG031097/AG/NIA NIH HHS/United States
GR  - P01 AG010435/AG/NIA NIH HHS/United States
GR  - P01 AG022074/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Apolipoprotein E4)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*blood/*genetics/psychology
MH  - Apathy/*physiology
MH  - Apolipoprotein E4/*genetics
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cognitive Dysfunction/blood/genetics/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Sex Characteristics
PMC - PMC4931817
MID - NIHMS798498
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - apathy
OT  - apolipoprotein E epsilon4 allele
OT  - brain-derived neurotrophic factor
OT  - elderly control subjects
OT  - mild cognitive impairment
OT  - serum
COIS- Disclosure statement The authors declare no conflicts of interest.
EDAT- 2014/07/16 06:00
MHDA- 2015/07/24 06:00
PMCR- 2016/07/04
CRDT- 2014/07/16 06:00
PHST- 2014/07/16 06:00 [entrez]
PHST- 2014/07/16 06:00 [pubmed]
PHST- 2015/07/24 06:00 [medline]
PHST- 2016/07/04 00:00 [pmc-release]
AID - V0601356878X66X7 [pii]
AID - 10.3233/JAD-140849 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2014;42(4):1347-55. doi: 10.3233/JAD-140849.