PMID- 2502526
OWN - NLM
STAT- MEDLINE
DCOM- 19890829
LR  - 20190723
IS  - 0021-8820 (Print)
IS  - 0021-8820 (Linking)
VI  - 42
IP  - 7
DP  - 1989 Jul
TI  - Inhibitory effect of antibiotic cerulenin on the respiratory burst in phagocytes. 
      I. Effects of cerulenin on active oxygen-generation and lipid metabolism in 
      phagocytes.
PG  - 1171-7
AB  - The antibiotic cerulenin, a known inhibitor of fatty acid and sterol synthesis, 
      inhibited bactericidal activity of mouse peritoneal macrophages and 
      chemiluminescence (CL) response upon phagocytosis. The antibiotic also inhibited 
      the CL response of human neutrophils upon exposure to various stimuli such as 
      chemotactic peptide N-formylmethionylleucylphenylalanine (fMLP), calcium 
      ionophore A23187 and Staphylococcal delta toxin. The loss of CL response of both 
      types of cells was observed only after incubation of the cells with cerulenin for 
      certain periods. The results of radioactive precursor incorporation suggest that 
      lipid metabolism blocked by cerulenin affected in turn signal transduction across 
      the cell membrane and inhibited CL production in these cells.
FAU - Nakata, M
AU  - Nakata M
AD  - Institute of Medical Science, University of Tokyo, Japan.
FAU - Tomita, T
AU  - Tomita T
FAU - Kanegasaki, S
AU  - Kanegasaki S
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Antibiot (Tokyo)
JT  - The Journal of antibiotics
JID - 0151115
RN  - 0 (Antifungal Agents)
RN  - 0 (Bacterial Toxins)
RN  - 0 (staphylococcal delta toxin)
RN  - 17397-89-6 (Cerulenin)
RN  - 37H9VM9WZL (Calcimycin)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Antifungal Agents/*pharmacology
MH  - Bacterial Toxins/pharmacology
MH  - Calcimycin/pharmacology
MH  - Cerulenin/*pharmacology
MH  - Female
MH  - Humans
MH  - *Lipid Metabolism
MH  - Luminescent Measurements
MH  - Macrophages/drug effects/metabolism
MH  - Mice
MH  - Mice, Inbred C3H
MH  - N-Formylmethionine Leucyl-Phenylalanine/pharmacology
MH  - Neutrophils/drug effects/metabolism
MH  - Oxygen/*metabolism
MH  - Peritoneal Cavity/cytology
MH  - Phagocytes/*drug effects/metabolism
MH  - Phagocytosis/*drug effects
MH  - Signal Transduction
EDAT- 1989/07/01 00:00
MHDA- 1989/07/01 00:01
CRDT- 1989/07/01 00:00
PHST- 1989/07/01 00:00 [pubmed]
PHST- 1989/07/01 00:01 [medline]
PHST- 1989/07/01 00:00 [entrez]
AID - 10.7164/antibiotics.42.1171 [doi]
PST - ppublish
SO  - J Antibiot (Tokyo). 1989 Jul;42(7):1171-7. doi: 10.7164/antibiotics.42.1171.