PMID- 25026537
OWN - NLM
STAT- MEDLINE
DCOM- 20150608
LR  - 20220309
IS  - 2158-0022 (Electronic)
IS  - 2158-0014 (Print)
IS  - 2158-0014 (Linking)
VI  - 4
IP  - 8
DP  - 2014 Oct
TI  - Differences and the relationship in default mode network intrinsic activity and 
      functional connectivity in mild Alzheimer's disease and amnestic mild cognitive 
      impairment.
PG  - 567-74
LID - 10.1089/brain.2014.0234 [doi]
AB  - There is evidence that the default mode network (DMN) functional connectivity is 
      impaired in Alzheimer's disease (AD) and few studies also reported a decrease in 
      DMN intrinsic activity, measured by the amplitude of low-frequency fluctuations 
      (ALFFs). In this study, we analyzed the relationship between DMN intrinsic 
      activity and functional connectivity, as well as their possible implications on 
      cognition in patients with mild AD and amnestic mild cognitive impairment (aMCI) 
      and healthy controls. In addition, we evaluated the differences both in 
      connectivity and ALFF values between these groups. We recruited 29 controls, 20 
      aMCI, and 32 mild AD patients. To identify the DMN, functional connectivity was 
      calculated by placing a seed in the posterior cingulate cortex (PCC). Within the 
      DMN mask obtained, we calculated regional average ALFFs. Compared with controls, 
      aMCI patients showed decreased ALFFs in the temporal region; compared with AD, 
      aMCI showed higher values in the PCC but lower in the temporal area. The mild AD 
      group had lower ALFFs in the PCC compared with controls. There was no difference 
      between the connectivity in the aMCI group compared with the other groups, but AD 
      patients showed decreased connectivity in the frontal, parietal, and PCC. Also, 
      PCC ALFFs correlated to functional connectivity in nearly all subregions. 
      Cognitive tests correlated to connectivity values but not to ALFFs. In 
      conclusion, we found that DMN connectivity and ALFFs are correlated in these 
      groups. Decreased PCC ALFFs disrupt the DMN functional organization, leading to 
      cognitive problems in the AD spectrum.
FAU - Weiler, Marina
AU  - Weiler M
AD  - 1 Laboratory of Neuroimaging, University of Campinas , Campinas, Brazil .
FAU - Teixeira, Camila Vieira Ligo
AU  - Teixeira CV
FAU - Nogueira, Mateus Henrique
AU  - Nogueira MH
FAU - de Campos, Brunno Machado
AU  - de Campos BM
FAU - Damasceno, Benito Pereira
AU  - Damasceno BP
FAU - Cendes, Fernando
AU  - Cendes F
FAU - Balthazar, Marcio Luiz Figueredo
AU  - Balthazar ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140919
PL  - United States
TA  - Brain Connect
JT  - Brain connectivity
JID - 101550313
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*physiopathology
MH  - Amnesia/*physiopathology
MH  - Brain/*physiopathology
MH  - Case-Control Studies
MH  - Cognitive Dysfunction/*physiopathology
MH  - Female
MH  - Frontal Lobe/physiopathology
MH  - Gyrus Cinguli/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/physiopathology
MH  - Parietal Lobe/physiopathology
MH  - Temporal Lobe/physiopathology
PMC - PMC4202997
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - amnestic mild cognitive impairment
OT  - dementia
OT  - episodic memory
OT  - functional MRI
EDAT- 2014/07/16 06:00
MHDA- 2015/06/09 06:00
PMCR- 2015/10/01
CRDT- 2014/07/16 06:00
PHST- 2014/07/16 06:00 [entrez]
PHST- 2014/07/16 06:00 [pubmed]
PHST- 2015/06/09 06:00 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - 10.1089/brain.2014.0234 [pii]
AID - 10.1089/brain.2014.0234 [doi]
PST - ppublish
SO  - Brain Connect. 2014 Oct;4(8):567-74. doi: 10.1089/brain.2014.0234. Epub 2014 Sep 
      19.