PMID- 25026798
OWN - NLM
STAT- MEDLINE
DCOM- 20140818
LR  - 20140716
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 86
IP  - 5
DP  - 2014
TI  - [Diagnostic value of the determination of angiogenic factors and cytokine 
      composition parameters in the serum and urine of patients with scleroderma 
      systematica].
PG  - 18-25
AB  - AIM: To study the associations of the concentration of interleukins (IL) 1beta, 
      6, 8, 10, monocyte chemoattractant protein-1 (MCP-1), tumor necrosis 
      factor-alpha, vascular endothelial growth factor (VEGF) in the serum and urine 
      with the clinical features of scleroderma systematica (SDS). SUBJECTS AND 
      METHODS: The investigation enrolled 51 patients with a valid SDS diagnosis. The 
      serum and urinary concentrations of interleukins, TNF-alpha, MCP-1, and VEGF were 
      measured by solid-phase enzyme immunoassay. RESULTS: The patients with SDS were 
      found to have higher serum and urine concentrations of proinflammatory cytokines 
      and VEGF than in the comparison group. There were relationships between the 
      levels of VEGF and proinflammatory cytokines and the disease duration, clinical 
      forms, and clinical manifestation of SDS. CONCLUSION: Higher serum VEGF levels in 
      patients with SDS may be used to estimate the magnitude of endothelial 
      dysfunction. Estimation of serum IL-6 concentrations may be employed to determine 
      the degree of sclerosis progression; that of MCP1 for the activity of fibrosing 
      alveolitis. Quantitative analysis of urinary IL-6, IL-8, and VEGF levels in 
      patients with SDS may be used to evaluate tubulointerstitial inflammation and to 
      predict the development of interstitial fibrosis.
FAU - Rebrov, A P
AU  - Rebrov AP
FAU - Patrikeeva, D A
AU  - Patrikeeva DA
FAU - Zakharova, N B
AU  - Zakharova NB
FAU - Karpova, O G
AU  - Karpova OG
FAU - Oksen'chuk, A N
AU  - Oksen'chuk AN
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/analysis
MH  - Disease Progression
MH  - Endothelium, Vascular/metabolism/physiopathology
MH  - Female
MH  - Humans
MH  - Inflammation/*metabolism
MH  - Interleukins/analysis
MH  - Male
MH  - Middle Aged
MH  - Neovascularization, Pathologic/*metabolism
MH  - Prognosis
MH  - *Scleroderma, Systemic/blood/diagnosis/physiopathology/urine
MH  - Statistics as Topic
MH  - Tumor Necrosis Factor-alpha/analysis
MH  - Vascular Endothelial Growth Factor A/analysis
EDAT- 2014/07/17 06:00
MHDA- 2014/08/19 06:00
CRDT- 2014/07/17 06:00
PHST- 2014/07/17 06:00 [entrez]
PHST- 2014/07/17 06:00 [pubmed]
PHST- 2014/08/19 06:00 [medline]
PST - ppublish
SO  - Ter Arkh. 2014;86(5):18-25.