PMID- 25027342
OWN - NLM
STAT- MEDLINE
DCOM- 20160912
LR  - 20181202
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 18
IP  - 14
DP  - 2014
TI  - Blood glucose fluctuation aggravates lower extremity vascular disease in type 2 
      diabetes.
PG  - 2025-30
LID - 7603 [pii]
AB  - OBJECTIVES: Lower-extremity vascular diseases are important complication of 
      diabetes. In the present study, we investigated the influence of blood glucose 
      fluctuation in type 2 diabetes-associated lower-extremity vascular diseases, and 
      explore the possible mechanism. PATIENTS AND METHODS: Patients with type 2 
      diabetes was assigned to Group B (without lower-extremity vascular disease) and 
      group C (with lower-extremity vascular disease). Healthy subjects (Group A) 
      served as normal controls. All patients received dynamic blood glucose monitoring 
      for 72 h. The mean amplitude of glycemic excursion (MAGE) and the largest 
      amplitude of glycemic excursion (LAGE) were estimated. The levels of von 
      Willebrand factor (vWF), ischemia-modified albumin (IMA), glycosylated hemoglobin 
      (HbA1c), and biochemical indices were examined, and the lower-extremity vascular 
      diseases were scored in patients from group C. RESULTS: Groups B and C have 
      higher systolic blood pressure (SBP), total cholesterol (TC) level, high-density 
      lipoprotein cholesterol (HDL-C) level, HbA1c level, and vWF level and lower IMA 
      level than those in Group A (p < 0.05). Elevated MAGE and LAGE were observed in 
      groups B and C as compared with Group A. Correlation analysis revealed that the 
      score of lower-extremity vascular diseases was associated with MAGE, LAGE, SBP, 
      LDL-C, vWF, HbA1c, and IMA (p < 0.05). Stepwise multiple-linear regression 
      analysis revealed that lower-extremity vascular diseases were involved with MAGE, 
      IMA, and vWF. CONCLUSIONS: Enhanced fluctuation in patients with type 2 diabetes 
      may promote the occurrence and development of lower-extremity vascular diseases 
      through aggravating vascular endothelial injury.
FAU - Jiao, X-M
AU  - Jiao XM
AD  - Endocrinology Department, the General Hospital of Beijing Military Area, Beijing, 
      China. xiaofenglv7966@163.com.
FAU - Zhang, X-G
AU  - Zhang XG
FAU - Xu, X U-P
AU  - Xu XU
FAU - Yi, C
AU  - Yi C
FAU - Bin, C
AU  - Bin C
FAU - Cheng, Q-P
AU  - Cheng QP
FAU - Gong, Q-Q
AU  - Gong QQ
FAU - Lv, X-F
AU  - Lv XF
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Serum Albumin)
RN  - 0 (ischemia-modified albumin)
RN  - ZIF514RVZR (Serum Albumin, Human)
SB  - IM
MH  - Biomarkers
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Diabetic Angiopathies/*blood
MH  - Female
MH  - Humans
MH  - Leg/*blood supply
MH  - Male
MH  - Middle Aged
MH  - Serum Albumin
MH  - Serum Albumin, Human
EDAT- 2014/07/17 06:00
MHDA- 2016/09/13 06:00
CRDT- 2014/07/17 06:00
PHST- 2014/07/17 06:00 [entrez]
PHST- 2014/07/17 06:00 [pubmed]
PHST- 2016/09/13 06:00 [medline]
AID - 7603 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2014;18(14):2025-30.