PMID- 25027671
OWN - NLM
STAT- MEDLINE
DCOM- 20150422
LR  - 20211021
IS  - 1179-1942 (Electronic)
IS  - 0114-5916 (Linking)
VI  - 37
IP  - 8
DP  - 2014 Aug
TI  - Undesirable effects related to oral antineoplastic drugs: comparison between 
      patients' internet narratives and a national pharmacovigilance database.
PG  - 629-37
LID - 10.1007/s40264-014-0203-6 [doi]
AB  - BACKGROUND: The Internet is changing the way people learn about health and 
      illness. Over the previous decade, the oral antineoplastic (OAN) agents have 
      changed patient management allowing more ambulatory care. In this regard, 
      websites could be an interesting source of data about OAN-induced adverse events 
      (AEs). OBJECTIVE: The aim of the study was to describe the characteristics of 
      AEs, as reported on websites by patients exposed to OAN agents, and to compare 
      these to those recorded in the French pharmacovigilance database (FPVD). METHODS: 
      We performed a retrospective study to collect AEs reported by patients in five of 
      the best-known website forums in France over 1 year (2011). For each report, we 
      recorded demographic data, cancer type, drug involved and AEs. The same analysis 
      was done in the FPVD for OAN-induced adverse drug reactions (ADRs). RESULTS: A 
      total of 202 AEs were identified in website posts and 1,448 ADRs were found in 
      the FPVD. The most cited drugs in websites were protein kinase inhibitors (n = 
      88, 43.5%) and hormone antagonists (n = 61, 30.2%). More musculoskeletal disorder 
      reports were found in the patient websites compared with the FPVD (16.34 vs. 
      4.70%, p < 0.001). As for skin disorders, we collected fewer reports in the 
      patient website forums than in the FPVD (13.37 vs. 22.17%, p = 0.004). AEs 
      reported in the patient websites were less serious (n = 10, 4.95%) than ADRs 
      recorded in the FPVD (n = 999, 68.99%) (p < 0.001). CONCLUSIONS: AEs reported in 
      the website forums are considered by patients to be relevant enough to be shared. 
      Data from patient websites could be used as a source of data to detect AEs 
      alongside conventional pharmacovigilance.
FAU - Pages, Arnaud
AU  - Pages A
AD  - Service de Pharmacologie Medicale et Clinique, Centre Midi-Pyrenees de 
      PharmacoVigilance, de Pharmacoepidemiologie et d'Informations sur le Medicament, 
      INSERM U1027, Faculte de Medecine, CHU de Toulouse, Universite de Toulouse, 37 
      Allees Jules Guesde, 31000, Toulouse, France.
FAU - Bondon-Guitton, Emmanuelle
AU  - Bondon-Guitton E
FAU - Montastruc, Jean Louis
AU  - Montastruc JL
FAU - Bagheri, Haleh
AU  - Bagheri H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - New Zealand
TA  - Drug Saf
JT  - Drug safety
JID - 9002928
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Administration, Oral
MH  - *Adverse Drug Reaction Reporting Systems
MH  - Antineoplastic Agents/administration & dosage/*adverse effects
MH  - *Databases, Factual
MH  - France
MH  - Humans
MH  - *Internet
MH  - *Pharmacovigilance
MH  - Retrospective Studies
MH  - *Self Report
EDAT- 2014/07/17 06:00
MHDA- 2015/04/23 06:00
CRDT- 2014/07/17 06:00
PHST- 2014/07/17 06:00 [entrez]
PHST- 2014/07/17 06:00 [pubmed]
PHST- 2015/04/23 06:00 [medline]
AID - 10.1007/s40264-014-0203-6 [doi]
PST - ppublish
SO  - Drug Saf. 2014 Aug;37(8):629-37. doi: 10.1007/s40264-014-0203-6.