PMID- 25029504
OWN - NLM
STAT- MEDLINE
DCOM- 20150512
LR  - 20221207
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 494-495
DP  - 2014 Oct 1
TI  - Stereoisomeric profiling of drugs of abuse and pharmaceuticals in wastewaters of 
      Valencia (Spain).
PG  - 49-57
LID - S0048-9697(14)00971-1 [pii]
LID - 10.1016/j.scitotenv.2014.06.098 [doi]
AB  - The enantiomeric and diastereomeric profiling of chiral pharmaceuticals 
      (ephedrine, norephedrine, atenolol and venlafaxine) and illicit drugs 
      (amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 
      3,4-methylenedioxy-N-methylamphetamine (MDMA) and 
      3,4-methylenedioxy-N-ethylamphetamine (MDEA)) was undertaken over a period of 
      fourteen consecutive days in three wastewater treatment plants (WWTPs) in the 
      city of Valencia, Spain. Degradation efficiency of WWTPs was found to be compound 
      and enantiomer dependent. Selective enantiomer enrichment was observed for 
      several target analytes. Amphetamine and MDMA were enriched with 
      R(-)-enantiomers. 1S,2S(+)-pseudoephedrine was found to be more readily 
      degradable during activated sludge treatment than its diastereomer 
      1R,2S(-)-ephedrine. Atenolol underwent enrichment with either S(-)- or 
      R(+)-enantiomer in different WWTPs. This unexpected enantiomeric variation in the 
      stereoselective degradation of atenolol could be attributed to different 
      processes utilized during activated sludge treatment. The application of 
      (enantiomeric) profiling of wastewater revealed usage patterns of chiral drugs in 
      the Valencia region.
CI  - Copyright (c) 2014. Published by Elsevier B.V.
FAU - Vazquez-Roig, Pablo
AU  - Vazquez-Roig P
AD  - Laboratory of Nutrition and Bromatology, Faculty of Pharmacy, University of 
      Valencia, Av. Vicent Andres s/n, 46100 Burjassot, Valencia, Spain.
FAU - Kasprzyk-Hordern, Barbara
AU  - Kasprzyk-Hordern B
AD  - University of Bath, Department of Chemistry, Faculty of Science, Bath BA2 7AY, 
      UK. Electronic address: B.Kasprzyk-Hordern@bath.ac.uk.
FAU - Blasco, Cristina
AU  - Blasco C
AD  - Laboratory of Nutrition and Bromatology, Faculty of Pharmacy, University of 
      Valencia, Av. Vicent Andres s/n, 46100 Burjassot, Valencia, Spain.
FAU - Pico, Yolanda
AU  - Pico Y
AD  - Laboratory of Nutrition and Bromatology, Faculty of Pharmacy, University of 
      Valencia, Av. Vicent Andres s/n, 46100 Burjassot, Valencia, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140712
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Illicit Drugs)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Waste Water)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - *Environmental Monitoring
MH  - Illicit Drugs/analysis
MH  - Pharmaceutical Preparations/*analysis
MH  - Spain
MH  - Stereoisomerism
MH  - Substance Abuse Detection/methods
MH  - Wastewater/*chemistry
MH  - Water Pollutants, Chemical/*analysis
OTO - NOTNLM
OT  - Chiral drugs
OT  - Drugs of abuse
OT  - Enantiomers
OT  - Pharmaceuticals
OT  - Stereoisomers
OT  - Wastewater
EDAT- 2014/07/17 06:00
MHDA- 2015/05/13 06:00
CRDT- 2014/07/17 06:00
PHST- 2014/05/31 00:00 [received]
PHST- 2014/06/21 00:00 [revised]
PHST- 2014/06/21 00:00 [accepted]
PHST- 2014/07/17 06:00 [entrez]
PHST- 2014/07/17 06:00 [pubmed]
PHST- 2015/05/13 06:00 [medline]
AID - S0048-9697(14)00971-1 [pii]
AID - 10.1016/j.scitotenv.2014.06.098 [doi]
PST - ppublish
SO  - Sci Total Environ. 2014 Oct 1;494-495:49-57. doi: 
      10.1016/j.scitotenv.2014.06.098. Epub 2014 Jul 12.