PMID- 25030036
OWN - NLM
STAT- MEDLINE
DCOM- 20160401
LR  - 20220316
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 56
IP  - 4
DP  - 2015 Apr
TI  - Prevalence of targetable oncogenic mutations and genomic alterations in 
      Epstein-Barr virus-associated diffuse large B-cell lymphoma of the elderly.
PG  - 1100-6
LID - 10.3109/10428194.2014.944522 [doi]
AB  - Epstein-Barr virus (EBV)-associated diffuse large B-cell lymphoma (DLBCL) of the 
      elderly constitutes a provisional clinicopathological entity in the current World 
      Health Organization (WHO) classification and its genomic features remain sparsely 
      characterized. We investigated a cohort of 26 cases of untreated de novo 
      EBV-positive DLBCL of the elderly by high-resolution array-based comparative 
      genomic profiling and fluorescence in situ hybridization (FISH). Moreover, we 
      screened for activating mutations affecting nuclear factor (NF)-kappaB pathway 
      signaling and chromatin remodeling (EZH2, CD79B, CARD11 and MYD88) due to their 
      impact of gene expression signatures and postulated upcoming therapeutic 
      targetability. We identified an overlap between genomic aberrations previously 
      described to be exclusive features of plasmablastic lymphoma (PL), 
      post-transplant lymphoproliferative disorder (PTLD) and DLBCL, respectively, 
      indicating a close cytogenetic relationship between these entities. Few mutations 
      affecting CD79B and CARD11 and no MYD88 mutations were detectable, hinting at 
      EBV-mediated activation of NF-kappaB as an alternative to pathologically enforced 
      B-cell receptor signaling in this rare entity.
FAU - Gebauer, Niklas
AU  - Gebauer N
AD  - Department of Internal Medicine I, University Hospital of Schleswig-Holstein , 
      Luebeck , Germany.
FAU - Gebauer, Judith
AU  - Gebauer J
FAU - Hardel, Tim Tristan
AU  - Hardel TT
FAU - Bernard, Veronica
AU  - Bernard V
FAU - Biersack, Harald
AU  - Biersack H
FAU - Lehnert, Hendrik
AU  - Lehnert H
FAU - Rades, Dirk
AU  - Rades D
FAU - Feller, Alfred Christian
AU  - Feller AC
FAU - Thorns, Christoph
AU  - Thorns C
LA  - eng
PT  - Journal Article
DEP - 20140821
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (CARD Signaling Adaptor Proteins)
RN  - 0 (CD79 Antigens)
RN  - 0 (MYD88 protein, human)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (Oncogene Proteins)
RN  - EC 4.6.1.2 (CARD11 protein, human)
RN  - EC 4.6.1.2 (Guanylate Cyclase)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - CARD Signaling Adaptor Proteins/genetics/metabolism
MH  - CD79 Antigens/genetics/metabolism
MH  - *Chromosome Aberrations
MH  - Comparative Genomic Hybridization
MH  - DNA Copy Number Variations
MH  - Epstein-Barr Virus Infections/*complications
MH  - Female
MH  - Guanylate Cyclase/genetics/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Large B-Cell, Diffuse/complications/epidemiology/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Mutation
MH  - Myeloid Differentiation Factor 88/genetics/metabolism
MH  - Oncogene Proteins/*genetics/metabolism
MH  - Prevalence
MH  - Tissue Array Analysis
OTO - NOTNLM
OT  - Epstein-Barr virus-associated diffuse large B-cell lymphoma of the elderly
OT  - NF-kappaB pathway
OT  - array comparative genomic hybridization
OT  - chromatin remodeling
EDAT- 2014/07/18 06:00
MHDA- 2016/04/02 06:00
CRDT- 2014/07/18 06:00
PHST- 2014/07/18 06:00 [entrez]
PHST- 2014/07/18 06:00 [pubmed]
PHST- 2016/04/02 06:00 [medline]
AID - 10.3109/10428194.2014.944522 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2015 Apr;56(4):1100-6. doi: 10.3109/10428194.2014.944522. Epub 
      2014 Aug 21.