PMID- 25030404
OWN - NLM
STAT- MEDLINE
DCOM- 20151222
LR  - 20211021
IS  - 1435-604X (Electronic)
IS  - 0268-8921 (Linking)
VI  - 30
IP  - 1
DP  - 2015 Jan
TI  - Effect of methylene blue-mediated photodynamic therapy for treatment of basal 
      cell carcinoma.
PG  - 109-15
LID - 10.1007/s10103-014-1609-1 [doi]
AB  - Photodynamic therapy (PDT) is regarded as a treatment option for basal cell 
      carcinoma (BCC). The aim of this study is to investigate the efficacy of 
      methylene blue (MB)-based PDT in patients suffering from nodular or ulcerative 
      BCCs. This study is a prospective clinical trial with a 6-months follow-up. The 
      study setting is at the Dermatology Clinic at NILES, Cairo University, Egypt. 
      Seventeen patients complaining of nodular BCC (nBCC) and three patients 
      complaining of ulcerative BCC (uBCC) were taken as samples. Methylene blue, the 
      photosensitizer, was prepared in two different formulas: liposomal-loaded MB 
      (LMB) was prepared and formulated in hydrogel (MB 0.2%) to be used topically 
      alone for treating BCCs <2 cm in diameter or to be combined with intralesional 
      injection (ILI) of free MB 2% aqueous solution for treating BCCs >/=2 cm in 
      diameter. A session was performed every 2 weeks until complete response (CR) of 
      the lesion or for a maximum of six sessions. Clinical assessments of clinical 
      improvement, dermatological photography, monthly follow-up visits for 6 months, 
      and skin biopsy after 3 months of follow-up to confirm the response, recurrence, 
      or both in cases in which the clinical evaluation was ambiguous. Seventeen 
      patients of the 20 completed the study, 11 patients achieved CR with very good 
      cosmetic outcome, photosensitizer tolerance, and minimal reported side effects. 
      MB is a cheap promising alternative photosensitizer for PDT of nBCC.
FAU - Samy, Nevien A
AU  - Samy NA
AD  - Dermatology Unit, Department of Medical Applications of Laser, National Institute 
      of Laser Enhanced Sciences (NILES), Cairo University, Cairo, Egypt, 
      nevien_a_sami@hotmail.com.
FAU - Salah, Manal M
AU  - Salah MM
FAU - Ali, Maha F
AU  - Ali MF
FAU - Sadek, Ahmed M
AU  - Sadek AM
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20140717
PL  - England
TA  - Lasers Med Sci
JT  - Lasers in medical science
JID - 8611515
RN  - 0 (Photosensitizing Agents)
RN  - 88755TAZ87 (Aminolevulinic Acid)
RN  - T42P99266K (Methylene Blue)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aminolevulinic Acid/therapeutic use
MH  - Carcinoma, Basal Cell/*drug therapy/pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Methylene Blue/*therapeutic use
MH  - Middle Aged
MH  - Photochemotherapy
MH  - Photosensitizing Agents/*therapeutic use
MH  - Prospective Studies
MH  - Remission Induction
MH  - Skin Neoplasms/*drug therapy/pathology
MH  - Treatment Outcome
EDAT- 2014/07/18 06:00
MHDA- 2015/12/23 06:00
CRDT- 2014/07/18 06:00
PHST- 2013/08/12 00:00 [received]
PHST- 2014/06/03 00:00 [accepted]
PHST- 2014/07/18 06:00 [entrez]
PHST- 2014/07/18 06:00 [pubmed]
PHST- 2015/12/23 06:00 [medline]
AID - 10.1007/s10103-014-1609-1 [doi]
PST - ppublish
SO  - Lasers Med Sci. 2015 Jan;30(1):109-15. doi: 10.1007/s10103-014-1609-1. Epub 2014 
      Jul 17.