PMID- 25030714
OWN - NLM
STAT- MEDLINE
DCOM- 20150515
LR  - 20191112
IS  - 2185-4610 (Electronic)
IS  - 0016-2590 (Linking)
VI  - 60
IP  - 1
DP  - 2014
TI  - Oral rabeprazole administration on a procedure day suppresses bleeding after 
      endoscopic submucosal dissection for gastric neoplasms.
PG  - 68-74
AB  - AIM: The efficacy of pre-procedure oral proton pump inhibitor (PPI) 
      administration for gastric endoscopic submucosal dissection (ESD) is unclear. 
      This study evaluated oral PPI administration effectiveness on the day of ESD to 
      prevent post-ESD bleeding. METHODS: This study examined 55 patients who underwent 
      ESD for gastric neoplasm. Group A comprised 31 patients who took rabeprazole 
      sodium (RPZ) 20 mg/day beginning 7-8 hr before ESD. Group B comprised 24 who took 
      RPZ 20 mg/day beginning three days before ESD. Gastric pH (G-pH) was measured at 
      one month before ESD (pre-ESD pH), immediately before ESD (ESD pH), and seven 
      days after ESD (post-ESD pH). The post-ESD bleeding rate and changes in G-pH were 
      recorded. RESULTS: No significant difference in post-ESD bleeding rates was found 
      (Group A 3.2%, Group B 0%). ESD pH and post-ESD pH were significantly higher than 
      pre-ESD pH in both groups (P<0.001). The ESD pH for Group A was higher than 6 
      (6.5+/-1.1), providing hemostasis for intragastric bleeding. CONCLUSIONS: Oral RPZ 
      administration on the day of gastric ESD can suppress post-ESD bleeding 
      equivalently to administration three days before ESD.
FAU - Hikichi, Takuto
AU  - Hikichi T
AD  - Department of Endoscopy, Fukushima Medical University Hospital.
FAU - Sato, Masaki
AU  - Sato M
FAU - Watanabe, Ko
AU  - Watanabe K
FAU - Nakamura, Jun
AU  - Nakamura J
FAU - Takagi, Tadayuki
AU  - Takagi T
FAU - Suzuki, Rei
AU  - Suzuki R
FAU - Sugimoto, Mitsuru
AU  - Sugimoto M
FAU - Waragai, Yuichi
AU  - Waragai Y
FAU - Kikuchi, Hitomi
AU  - Kikuchi H
FAU - Konno, Naoki
AU  - Konno N
FAU - Ohira, Hiromasa
AU  - Ohira H
FAU - Obara, Katsutoshi
AU  - Obara K
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20140715
PL  - Japan
TA  - Fukushima J Med Sci
JT  - Fukushima journal of medical science
JID - 0374626
RN  - 0 (Proton Pump Inhibitors)
RN  - 32828355LL (Rabeprazole)
SB  - IM
MH  - Adenocarcinoma/surgery
MH  - Adenoma/surgery
MH  - Administration, Oral
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Gastrointestinal Hemorrhage/*prevention & control
MH  - Gastroscopy/adverse effects/methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postoperative Hemorrhage/*prevention & control
MH  - Proton Pump Inhibitors/*administration & dosage
MH  - Rabeprazole/*administration & dosage
MH  - Stomach Neoplasms/*surgery
EDAT- 2014/07/18 06:00
MHDA- 2015/05/16 06:00
CRDT- 2014/07/18 06:00
PHST- 2014/07/18 06:00 [entrez]
PHST- 2014/07/18 06:00 [pubmed]
PHST- 2015/05/16 06:00 [medline]
AID - DN/JST.JSTAGE/fms/2013-17 [pii]
AID - 10.5387/fms.2013-17 [doi]
PST - ppublish
SO  - Fukushima J Med Sci. 2014;60(1):68-74. doi: 10.5387/fms.2013-17. Epub 2014 Jul 
      15.