PMID- 25031604 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20140717 LR - 20211021 IS - 1741-427X (Print) IS - 1741-4288 (Electronic) IS - 1741-427X (Linking) VI - 2014 DP - 2014 TI - Cognitive-Enhancing Effect of Steamed and Fermented Codonopsis lanceolata: A Behavioral and Biochemical Study. PG - 319436 LID - 10.1155/2014/319436 [doi] LID - 319436 AB - Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment. Codonopsis lanceolata (C. lanceolata) has been employed clinically for lung inflammatory diseases such as asthma, tonsillitis, and pharyngitis. The present study was undertaken to evaluate the effect of fermented C. lanceolata (300, 500, and 800 mg/kg) on learning and memory impairment induced by scopolamine by using the Morris water maze and passive avoidance tests. To elucidate possible mechanism of cognitive-enhancing activity, we measured acetylcholinesterase (AchE) activity, brain-derived neurotrophic factor (BDNF), and cyclic AMP response element-binding protein (CREB) expression in the brain of mice. Administration of fermented C. lanceolata (800 mg/kg) led to reduced scopolamine-induced memory impairment in the Morris water maze and passive avoidance tests. Accordingly, the administration of fermented C. lanceolata inhibited AchE activity. Interestingly, the level of CREB phosphorylation and BDNF expression in hippocampal tissue of scopolamine-treated mice was significantly increased by the administration of fermented C. lanceolata. These results indicate that fermented C. lanceolata can ameliorate scopolamine-induced memory deficits in mouse and may be an alternative agent for the treatment of AD. FAU - Weon, Jin Bae AU - Weon JB AD - Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Hyoja-2 Dong, Chuncheon 200-701, Republic of Korea. FAU - Yun, Bo-Ra AU - Yun BR AD - Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Hyoja-2 Dong, Chuncheon 200-701, Republic of Korea. FAU - Lee, Jiwoo AU - Lee J AD - Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Hyoja-2 Dong, Chuncheon 200-701, Republic of Korea. FAU - Eom, Min Rye AU - Eom MR AD - Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Hyoja-2 Dong, Chuncheon 200-701, Republic of Korea. FAU - Ko, Hyun-Jeong AU - Ko HJ AUID- ORCID: 0000-0002-3844-928X AD - Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon 200-701, Republic of Korea. FAU - Lee, Hyeon Yong AU - Lee HY AD - Department of Teaics, Seowon University, Cheongju 361-742, Republic of Korea. FAU - Park, Dong-Sik AU - Park DS AD - Functional Food & Nutrition Division, Department of Agrofood Resources, Rural Development Administration, Suwon 441-853, Republic of Korea. FAU - Chung, Hee-Chul AU - Chung HC AD - Newtree Co., Ltd., 11F Tech Center, SKnTechno Park 190-1, Sungnam 462-120, Republic of Korea. FAU - Chung, Jae Youn AU - Chung JY AD - Newtree Co., Ltd., 11F Tech Center, SKnTechno Park 190-1, Sungnam 462-120, Republic of Korea. FAU - Ma, Choong Je AU - Ma CJ AD - Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Hyoja-2 Dong, Chuncheon 200-701, Republic of Korea ; Research Institute of Biotechnology, Kangwon National University, Chuncheon 200-701, Republic of Korea. LA - eng PT - Journal Article DEP - 20140616 PL - United States TA - Evid Based Complement Alternat Med JT - Evidence-based complementary and alternative medicine : eCAM JID - 101215021 PMC - PMC4083609 EDAT- 2014/07/18 06:00 MHDA- 2014/07/18 06:01 PMCR- 2014/06/16 CRDT- 2014/07/18 06:00 PHST- 2014/05/01 00:00 [received] PHST- 2014/05/26 00:00 [revised] PHST- 2014/05/27 00:00 [accepted] PHST- 2014/07/18 06:00 [entrez] PHST- 2014/07/18 06:00 [pubmed] PHST- 2014/07/18 06:01 [medline] PHST- 2014/06/16 00:00 [pmc-release] AID - 10.1155/2014/319436 [doi] PST - ppublish SO - Evid Based Complement Alternat Med. 2014;2014:319436. doi: 10.1155/2014/319436. Epub 2014 Jun 16.