PMID- 25031858
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140717
LR  - 20240321
IS  - 2074-1804 (Print)
IS  - 2074-1812 (Electronic)
IS  - 2074-1804 (Linking)
VI  - 16
IP  - 5
DP  - 2014 May
TI  - Hydro-methanolic extract of cornus MAS L. And blood glucose, lipid profile and 
      hematological parameters of male rats.
PG  - e17784
LID - 10.5812/ircmj.17784 [doi]
LID - e17784
AB  - BACKGROUND: Cornus mas L, an olive-shaped red-colored single-seeded fruit, is 
      used in traditional medicine in different parts of Europe and Asia. OBJECTIVES: 
      In the present study, 40 male Wistar rats were randomly divided into five groups, 
      and the effects of 21 days of intraperitoneally (IP) administration of 50, 200 
      and 400 mg/kg body weight of C. mas hydro-methanolic extract on the rats 
      hematological and biochemical parameters were investigated. The experimental 
      study was carried out in Tabriz, Iran. MATERIALS AND METHODS: The hematology and 
      biochemical tests were performed by the Technicon H1 Hematology Analyzer and 
      enzymatic methods, respectively. RESULTS: The results indicated that all doses of 
      the extract caused significant (P < 0.05) decreases in the hemoglobin 
      distribution width (HDW) (2.3 +/- 0.2 vs. 2.5 +/- 0.2, P = 0.049) and platelet 
      distribution width (PDW) (56.5 +/- 1.8 vs. 63.9 +/- 3.6, P = 0.001) of the treated 
      groups vs. control group, whereas only high doses caused significant elevation in 
      the mean corpuscular hemoglobin concentration (MCHC) (30.3 +/- 0.8 vs. 28.6 +/- 0.6, 
      P = 0.047), mean platelet volume (MPV) (5.0 +/- 0.6 vs. 4.1 +/- 0.3, P = 0.002), 
      total platelet mass (PCT) (0.33 +/- 0.07 vs. 0.26 +/- 0.01, P = 0.050), and 
      significant decrease in the red cell distribution width (RDW) (13.8 +/- 0.4 vs. 
      14.7 +/- 1.3, P = 0.048) of the treated groups vs. control group. CONCLUSIONS: 
      Decreasing effect of the extract on platelet activity might classify it as an 
      alternative for antiplatelet therapy in cardiovascular diseases (CVD). The 
      results of this study suggested that further investigations with higher doses of 
      C. mas fruit extract are necessary to obtain significant protective and 
      nonprotective changes in hematological and biochemical parameters.
FAU - Abdollahi, Bita
AU  - Abdollahi B
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IR 
      Iran.
FAU - Mesgari Abbasi, Mehran
AU  - Mesgari Abbasi M
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IR 
      Iran ; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, 
      IR Iran.
FAU - Zakeri Milani, Parvin
AU  - Zakeri Milani P
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, IR 
      Iran.
FAU - Nourdadgar, Ashraf Sadat
AU  - Nourdadgar AS
AD  - Medical Education Research Center, Tabriz University of Medical Sciences, Tabriz, 
      IR Iran.
FAU - Banan Khojasteh, Seyyed Mehdi
AU  - Banan Khojasteh SM
AD  - Department of Natural Sciences, Faculty of Natural Sciences, University of 
      Tabriz, Tabriz, IR Iran.
FAU - Nejati, Vahid
AU  - Nejati V
AD  - Faculty of Science, Urmia University, Urmia, IR Iran.
LA  - eng
PT  - Journal Article
DEP - 20140505
PL  - Estonia
TA  - Iran Red Crescent Med J
JT  - Iranian Red Crescent medical journal
JID - 101319850
PMC - PMC4082518
OTO - NOTNLM
OT  - Biological Markers
OT  - Blood Glucose
OT  - Cornus
OT  - Hematologic Tests
EDAT- 2014/07/18 06:00
MHDA- 2014/07/18 06:01
PMCR- 2014/05/01
CRDT- 2014/07/18 06:00
PHST- 2014/01/23 00:00 [received]
PHST- 2014/03/19 00:00 [revised]
PHST- 2014/04/01 00:00 [accepted]
PHST- 2014/07/18 06:00 [entrez]
PHST- 2014/07/18 06:00 [pubmed]
PHST- 2014/07/18 06:01 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - 10.5812/ircmj.17784 [doi]
PST - ppublish
SO  - Iran Red Crescent Med J. 2014 May;16(5):e17784. doi: 10.5812/ircmj.17784. Epub 
      2014 May 5.