PMID- 25033082
OWN - NLM
STAT- MEDLINE
DCOM- 20151106
LR  - 20211021
IS  - 1553-7374 (Electronic)
IS  - 1553-7366 (Print)
IS  - 1553-7366 (Linking)
VI  - 10
IP  - 7
DP  - 2014 Jul
TI  - HIV-1 capture and transmission by dendritic cells: the role of viral glycolipids 
      and the cellular receptor Siglec-1.
PG  - e1004146
LID - 10.1371/journal.ppat.1004146 [doi]
LID - e1004146
AB  - Dendritic cells (DCs) are essential in order to combat invading viruses and 
      trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might 
      contribute to viral pathogenesis through trans-infection, a mechanism that 
      promotes viral capture and transmission to target cells, especially after DC 
      maturation. In this review, we highlight recent evidence identifying 
      sialyllactose-containing gangliosides in the viral membrane and the cellular 
      lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature 
      DCs and for DC-mediated trans-infection of T cells. In contrast, DC-SIGN, long 
      considered to be the main receptor for DC capture of HIV-1, plays a minor role in 
      mature DC-mediated HIV-1 capture and trans-infection.
FAU - Izquierdo-Useros, Nuria
AU  - Izquierdo-Useros N
AD  - AIDS Research Institute IrsiCaixa, Institut d'Investigacio en Ciencies de la 
      Salut Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain.
FAU - Lorizate, Maier
AU  - Lorizate M
AD  - Unidad de Biofisica (CSIC-UPV/EHU) and Departamento de Bioquimica, Universidad 
      del Pais Vasco, Bilbao, Spain.
FAU - McLaren, Paul J
AU  - McLaren PJ
AD  - Institute of Microbiology, University Hospital Center and University of Lausanne, 
      Lausanne, Switzerland.
FAU - Telenti, Amalio
AU  - Telenti A
AD  - Institute of Microbiology, University Hospital Center and University of Lausanne, 
      Lausanne, Switzerland.
FAU - Krausslich, Hans-Georg
AU  - Krausslich HG
AD  - Department of Infectious Diseases, Virology, Universitatsklinikum Heidelberg, 
      Heidelberg, Germany.
FAU - Martinez-Picado, Javier
AU  - Martinez-Picado J
AD  - AIDS Research Institute IrsiCaixa, Institut d'Investigacio en Ciencies de la 
      Salut Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain; 
      Universitat de Vic-Universitat Central de Catalunya (UVic-UCC), Vic, Spain; 
      Institucio Catalana de Recerca i Estudis Avancats (ICREA), Barcelona, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140717
PL  - United States
TA  - PLoS Pathog
JT  - PLoS pathogens
JID - 101238921
RN  - 0 (Glycolipids)
RN  - 0 (SIGLEC1 protein, human)
RN  - 0 (Sialic Acid Binding Ig-like Lectin 1)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/pathology/virology
MH  - Glycolipids/*immunology
MH  - HIV Infections/*immunology/pathology
MH  - HIV-1/*immunology
MH  - Humans
MH  - Sialic Acid Binding Ig-like Lectin 1/*immunology
MH  - T-Lymphocytes/*immunology/pathology
PMC - PMC4102576
COIS- The authors have declared that no competing interests exist.
EDAT- 2014/07/18 06:00
MHDA- 2015/11/07 06:00
PMCR- 2014/07/17
CRDT- 2014/07/18 06:00
PHST- 2014/07/18 06:00 [entrez]
PHST- 2014/07/18 06:00 [pubmed]
PHST- 2015/11/07 06:00 [medline]
PHST- 2014/07/17 00:00 [pmc-release]
AID - PPATHOGENS-D-14-00433 [pii]
AID - 10.1371/journal.ppat.1004146 [doi]
PST - epublish
SO  - PLoS Pathog. 2014 Jul 17;10(7):e1004146. doi: 10.1371/journal.ppat.1004146. 
      eCollection 2014 Jul.