PMID- 25034112
OWN - NLM
STAT- MEDLINE
DCOM- 20141106
LR  - 20140915
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 158
IP  - 4
DP  - 2014 Oct
TI  - The lack of concordance between subretinal drusenoid deposits and large choroidal 
      blood vessels.
PG  - 710-5
LID - S0002-9394(14)00400-0 [pii]
LID - 10.1016/j.ajo.2014.07.009 [doi]
AB  - PURPOSE: To evaluate the concordance between pseudodrusen as manifested by 
      subretinal drusenoid deposits and large choroidal blood vessels using 
      stereological analysis of spectral-domain optical coherence tomography (SD OCT) 
      images. DESIGN: Retrospective, observational case series. METHODS: The SD OCT 
      images of 31 consecutive patients with the clinical appearance of pseudodrusen 
      from a private-referral retinal clinic were retrospectively reviewed. A grid of 
      19 evenly spaced vertical lines was randomly superimposed on each SD OCT image 
      using ImageJ to perform systematic uniform random sampling. The main outcome 
      measure was the likelihood of association between subretinal drusenoid deposits 
      and large choroidal vessels. RESULTS: Uniform random systematic sampling of 589 
      samples found the proportion of geometric probes intersecting subretinal 
      drusenoid deposits to be 0.28, large choroidal vessel 0.65, and both 0.19. This 
      value was nearly identical to the product of the joint probabilities and was 
      within the 95% confidence interval (0.15-0.21) of the point estimate as 
      calculated by the binomial theorem, indicating mutual independence. The 
      subretinal drusenoid deposits were associated with neither large choroidal 
      vessels nor the intervals in between. CONCLUSIONS: Our results demonstrate that 
      there is no concordance between subretinal drusenoid deposits and large choroidal 
      vessels or the stroma in between. As a consequence, hypotheses postulating that 
      subretinal drusenoid deposits are associated with large choroidal vessels or the 
      choroidal stromal spaces should be abandoned. Stereological techniques are 
      powerful methods used in image evaluation in other fields of study and appear to 
      have utility in analyzing OCT findings of the retina and choroid.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Vongkulsiri, Sritatath
AU  - Vongkulsiri S
AD  - Vitreous Retina Macula Consultants of New York and LuEsther T. Mertz Retinal 
      Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York.
FAU - Ooto, Sotaro
AU  - Ooto S
AD  - Vitreous Retina Macula Consultants of New York and LuEsther T. Mertz Retinal 
      Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York.
FAU - Mrejen, Sarah
AU  - Mrejen S
AD  - Vitreous Retina Macula Consultants of New York and LuEsther T. Mertz Retinal 
      Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York.
FAU - Suzuki, Mihoko
AU  - Suzuki M
AD  - Vitreous Retina Macula Consultants of New York and LuEsther T. Mertz Retinal 
      Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York.
FAU - Spaide, Richard F
AU  - Spaide RF
AD  - Vitreous Retina Macula Consultants of New York and LuEsther T. Mertz Retinal 
      Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York. 
      Electronic address: rick.spaide@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20140715
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroid/*blood supply
MH  - Ciliary Arteries/*pathology
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Macular Degeneration/*diagnosis
MH  - Male
MH  - Retinal Drusen/*diagnosis
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/methods
EDAT- 2014/07/19 06:00
MHDA- 2014/11/07 06:00
CRDT- 2014/07/19 06:00
PHST- 2014/01/21 00:00 [received]
PHST- 2014/06/30 00:00 [revised]
PHST- 2014/07/03 00:00 [accepted]
PHST- 2014/07/19 06:00 [entrez]
PHST- 2014/07/19 06:00 [pubmed]
PHST- 2014/11/07 06:00 [medline]
AID - S0002-9394(14)00400-0 [pii]
AID - 10.1016/j.ajo.2014.07.009 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2014 Oct;158(4):710-5. doi: 10.1016/j.ajo.2014.07.009. Epub 2014 
      Jul 15.