PMID- 25034568
OWN - NLM
STAT- MEDLINE
DCOM- 20150730
LR  - 20141101
IS  - 1399-3003 (Electronic)
IS  - 0903-1936 (Linking)
VI  - 44
IP  - 5
DP  - 2014 Nov
TI  - Human leukocyte antigen class II variants and adult-onset asthma: does 
      occupational allergen exposure play a role?
PG  - 1234-42
LID - 10.1183/09031936.00068014 [doi]
AB  - Recently, a locus centred on rs9273349 in the HLA-DQ region emerged from 
      genome-wide association studies of adult-onset asthma. We aimed to further 
      investigate the role of human leukocyte antigen (HLA) class II in adult-onset 
      asthma and a possible interaction with occupational exposures. We imputed 
      classical HLA-II alleles from 7579 single-nucleotide polymorphisms in 6025 
      subjects (1202 with adult-onset asthma) from European cohorts: ECRHS, SAPALDIA, 
      EGEA and B58C, and from surveys of bakers and agricultural workers. Based on an 
      asthma-specific job-exposure matrix, 2629 subjects had ever been exposed to high 
      molecular weight (HMW) allergens. We explored associations between 23 common 
      HLA-II alleles and adult-onset asthma, and tested for gene-environment 
      interaction with occupational exposure to HMW allergens. Interaction was also 
      tested for rs9273349. Marginal associations of classical HLA-II alleles and 
      adult-onset asthma were not statistically significant. Interaction was detected 
      between the DPB1*03:01 allele and exposure to HMW allergens (p = 0.009), in 
      particular to latex (p = 0.01). In the unexposed group, the DPB1*03:01 allele was 
      associated with adult-onset asthma (OR 0.67, 95%CI 0.53-0.86). HMW allergen 
      exposures did not modify the association of rs9273349 with adult-onset asthma. 
      Common classical HLA-II alleles were not marginally associated with adult-onset 
      asthma. The association of latex exposure and adult-onset asthma may be modified 
      by DPB1*03:01.
CI  - (c)ERS 2014.
FAU - Smit, Lidwien A M
AU  - Smit LA
AD  - For the authors' affiliations see the Acknowledgements section l.a.smit@uu.nl.
FAU - Strachan, David P
AU  - Strachan DP
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Vermeulen, Roel
AU  - Vermeulen R
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - de Bakker, Paul I W
AU  - de Bakker PI
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Demenais, Florence
AU  - Demenais F
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Dumas, Orianne
AU  - Dumas O
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Carsin, Anne-Elie
AU  - Carsin AE
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Cullinan, Paul
AU  - Cullinan P
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Curjuric, Ivan
AU  - Curjuric I
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Ghosh, Rebecca E
AU  - Ghosh RE
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Heederik, Dick
AU  - Heederik D
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Imboden, Medea
AU  - Imboden M
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Jarvis, Deborah
AU  - Jarvis D
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Lathrop, Mark
AU  - Lathrop M
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Le Moual, Nicole
AU  - Le Moual N
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Mehta, Amar
AU  - Mehta A
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Miedinger, David
AU  - Miedinger D
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Sigsgaard, Torben
AU  - Sigsgaard T
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Siroux, Valerie
AU  - Siroux V
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Vernez, David
AU  - Vernez D
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Zock, Jan Paul
AU  - Zock JP
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Kauffmann, Francine
AU  - Kauffmann F
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Probst-Hensch, Nicole
AU  - Probst-Hensch N
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Kogevinas, Manolis
AU  - Kogevinas M
AD  - For the authors' affiliations see the Acknowledgements section.
FAU - Bouzigon, Emmanuelle
AU  - Bouzigon E
AD  - For the authors' affiliations see the Acknowledgements section.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20140717
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Allergens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Allergens/*immunology
MH  - Asthma/*genetics/*immunology/physiopathology
MH  - Cohort Studies
MH  - Europe
MH  - Female
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ beta-Chains/genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Histocompatibility Antigens Class II/*genetics/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Weight
MH  - *Occupational Exposure
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
MH  - Young Adult
EDAT- 2014/07/19 06:00
MHDA- 2015/08/01 06:00
CRDT- 2014/07/19 06:00
PHST- 2014/07/19 06:00 [entrez]
PHST- 2014/07/19 06:00 [pubmed]
PHST- 2015/08/01 06:00 [medline]
AID - 09031936.00068014 [pii]
AID - 10.1183/09031936.00068014 [doi]
PST - ppublish
SO  - Eur Respir J. 2014 Nov;44(5):1234-42. doi: 10.1183/09031936.00068014. Epub 2014 
      Jul 17.