PMID- 25034590 OWN - NLM STAT- MEDLINE DCOM- 20150716 LR - 20230926 IS - 1999-6187 (Electronic) IS - 1009-3419 (Print) IS - 1009-3419 (Linking) VI - 17 IP - 7 DP - 2014 Jul 20 TI - [Treatment progress for EGFR wild-type advanced non-small cell lung cancer]. PG - 575-80 LID - 10.3779/j.issn.1009-3419.2014.07.14 [doi] AB - Lung cancer is the leading cause of death from cancer in the world. The treatment remains one of the most challenging tasks in the medical world. The discovery and development of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) have had a major impact in the treatment of non small cell lung cancer (NSCLC). But the efficacy of EGFR-TKI in EGFR wild-type patients is limited, and the limited EGFR mutation incidence also prompts researchers to study what is the best treatment choice for patients with NSCLC who are negative for EGFR mutations. This review will discuss the research status in treatment choice for EGFR wild-type NSCLC. FAU - Ma, Feng AU - Ma F AD - Department of Medical Oncology, the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China. FAU - Shi, Xiaoyu AU - Shi X AD - Department of Medical Oncology, the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China. FAU - Meng, Wei AU - Meng W AD - Department of Medical Oncology, the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China. FAU - Zhang, Jing AU - Zhang J AD - Department of Medical Oncology, the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China. FAU - Zhao, Lixia AU - Zhao L AD - Department of Medical Oncology, the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China. FAU - He, Xiaohua AU - He X AD - Department of Medical Oncology, the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China. FAU - Zhao, Junfeng AU - Zhao J AD - Department of Medical Oncology, the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China. LA - chi PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - China TA - Zhongguo Fei Ai Za Zhi JT - Zhongguo fei ai za zhi = Chinese journal of lung cancer JID - 101126433 RN - 0 (Antineoplastic Agents) RN - 0 (Protein Kinase Inhibitors) RN - EC 2.7.10.1 (ErbB Receptors) SB - IM MH - Antineoplastic Agents/*therapeutic use MH - Carcinoma, Non-Small-Cell Lung/*drug therapy/enzymology/genetics MH - ErbB Receptors/*antagonists & inhibitors/genetics MH - Humans MH - Lung Neoplasms/*drug therapy/enzymology/genetics MH - Protein Kinase Inhibitors/*therapeutic use PMC - PMC6000467 EDAT- 2014/07/19 06:00 MHDA- 2015/07/17 06:00 PMCR- 2014/07/20 CRDT- 2014/07/19 06:00 PHST- 2014/07/19 06:00 [entrez] PHST- 2014/07/19 06:00 [pubmed] PHST- 2015/07/17 06:00 [medline] PHST- 2014/07/20 00:00 [pmc-release] AID - zgfazz-17-7-575 [pii] AID - 10.3779/j.issn.1009-3419.2014.07.14 [doi] PST - ppublish SO - Zhongguo Fei Ai Za Zhi. 2014 Jul 20;17(7):575-80. doi: 10.3779/j.issn.1009-3419.2014.07.14.