PMID- 25035279
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140718
LR  - 20211021
IS  - 2051-817X (Print)
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 2
IP  - 7
DP  - 2014 Jul 1
TI  - Delay of left ventricular longitudinal expansion with diastolic dysfunction: 
      impact on load dependence of e' and longitudinal strain rate.
LID - 10.14814/phy2.12082 [doi]
LID - e12082
AB  - The effect of diastolic dysfunction (DD) on the timing of left ventricular (LV) 
      diastolic longitudinal and circumferential expansion and their load dependence is 
      not known. This study evaluated the timing of the peak early diastolic LV inflow 
      velocity (E), mitral annular velocity (e'), and longitudinal and circumferential 
      global strain rates (SRE) in 161 patients in sinus rhythm. The intraventricular 
      pressure difference (IVPD) from the left atrium to the LV apex was obtained using 
      color M-mode Doppler data to integrate the Euler equation. The diastolic function 
      was graded according to the guidelines. In normals (N = 57), E, e', longitudinal 
      SRE, and circumferential SRE occurred nearly simultaneously during the IVPD. With 
      DD (N = 104), e' and longitudinal SRE were delayed occurring after the IVPD (e': 
      18 +/- 23 msec, longitudinal SRE: 13 +/- 21 msec from the IVPD), whereas 
      circumferential SRE (-8 +/- 28 msec) and E (-2 +/- 13 msec) were not delayed. The 
      normal dependence of e' and longitudinal SRE on IVPD was reduced in DD; while the 
      relation of circumferential SRE and E to IVPD were unchanged in DD. Thus, 
      normally, the LV expands symmetrically during early diastole and both 
      longitudinal and circumferential expansions are related to the IVPD. With DD, 
      early diastolic longitudinal LV expansion is delayed, occurring after the IVPD 
      and LV filling, resulting in their relative independence from the IVPD. In 
      contrast, with DD, circumferential SRE and mitral inflow are not delayed and 
      their normal relation to the IVPD is unchanged.
CI  - (c) 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on 
      behalf of the American Physiological Society and The Physiological Society.
FAU - Iwano, Hiroyuki
AU  - Iwano H
AD  - Division of Cardiology, University of Mississippi Medical Center, Jackson, 
      Mississippi, USA.
FAU - Pu, Min
AU  - Pu M
AD  - Cardiology Section, Wake Forest School of Medicine, Winston-Salem, North 
      California, USA.
FAU - Upadhya, Bharathi
AU  - Upadhya B
AD  - Cardiology Section, Wake Forest School of Medicine, Winston-Salem, North 
      California, USA.
FAU - Meyers, Brett
AU  - Meyers B
AD  - Department of Mechanical Engineering, Virginia Tech, Blacksburg, Virginia, USA.
FAU - Vlachos, Pavlos
AU  - Vlachos P
AD  - School of Mechanical Engineering, Purdue University, West Lafayette, Indiana, 
      USA.
FAU - Little, William C
AU  - Little WC
AD  - Division of Cardiology, University of Mississippi Medical Center, Jackson, 
      Mississippi, USA.
LA  - eng
GR  - R21 HL106276/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20140716
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
PMC - PMC4187544
OTO - NOTNLM
OT  - Echocardiography
OT  - heart failure
OT  - intra left ventricular pressure difference
OT  - left ventricular diastolic function
EDAT- 2014/07/19 06:00
MHDA- 2014/07/19 06:01
PMCR- 2014/07/17
CRDT- 2014/07/19 06:00
PHST- 2014/07/19 06:00 [entrez]
PHST- 2014/07/19 06:00 [pubmed]
PHST- 2014/07/19 06:01 [medline]
PHST- 2014/07/17 00:00 [pmc-release]
AID - 2/7/e12082 [pii]
AID - phy212082 [pii]
AID - 10.14814/phy2.12082 [doi]
PST - epublish
SO  - Physiol Rep. 2014 Jul 16;2(7):e12082. doi: 10.14814/phy2.12082. Print 2014 Jul 1.