PMID- 25036427
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20160513
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 273
DP  - 2014 Oct 15
TI  - Sex differences in adolescent methylphenidate sensitization: effects on glial 
      cell-derived neurotrophic factor and brain-derived neurotrophic factor.
PG  - 139-43
LID - S0166-4328(14)00454-9 [pii]
LID - 10.1016/j.bbr.2014.07.014 [doi]
AB  - This study analyzed sex differences in methylphenidate (MPH) sensitization and 
      corresponding changes in glial cell-derived neurotrophic factor (GDNF) and 
      brain-derived neurotprhic factor protein (BDNF) in adolescent male and female 
      rats. After habituation to a locomotor arena, animals were sensitized to MPH 
      (5mg/kg) or saline from postnatal day (P) 33-49, tested every second day. On P50, 
      one group of animals were injected with saline and behavior assessed for 
      conditioned hyperactivity. Brain tissue was harvested on P51 and analyzed for 
      GDNF protein. A second group of animals was also sensitized to MPH from P33 to 
      49, and expression of behavioral sensitization was analyzed on a challenge given 
      at P60, and BDNF protein analyzed at P61. Females demonstrated more robust 
      sensitization to MPH than males, but only females given MPH during sensitization 
      demonstrated conditioned hyperactivity. Interestingly, MPH resulted in a 
      significant increase in striatal and accumbal GDNF with no sex differences 
      revealed. Results of the challenge revealed that females sensitized and 
      challenged with MPH demonstrated increased activity compared to all other groups. 
      Regarding BDNF, only males given MPH demonstrated an increase in dorsal striatum, 
      whereas MPH increased accumbal BDNF with no sex differences revealed. A 
      hierarchical regression analysis revealed that behavioral sensitization and the 
      conditioned hyperactivity test were reliable predictors of striatal and accumbal 
      GDNF, whereas sensitization and activity on the challenge were reliable 
      predictors of accumbal BDNF, but had no relationship to striatal BDNF. These data 
      have implications for the role of MPH in addiction and dopamine system 
      plasticity.
CI  - Copyright (c) 2014. Published by Elsevier B.V.
FAU - Roeding, Ross L
AU  - Roeding RL
AD  - Department of Psychology East Tennessee State University, Johnson City, TN 37614, 
      USA.
FAU - Perna, Marla K
AU  - Perna MK
AD  - Department of Psychology East Tennessee State University, Johnson City, TN 37614, 
      USA.
FAU - Cummins, Elizabeth D
AU  - Cummins ED
AD  - Department of Psychology East Tennessee State University, Johnson City, TN 37614, 
      USA.
FAU - Peterson, Daniel J
AU  - Peterson DJ
AD  - Department of Psychology East Tennessee State University, Johnson City, TN 37614, 
      USA.
FAU - Palmatier, Matthew I
AU  - Palmatier MI
AD  - Department of Psychology East Tennessee State University, Johnson City, TN 37614, 
      USA.
FAU - Brown, Russell W
AU  - Brown RW
AD  - Department of Psychology East Tennessee State University, Johnson City, TN 37614, 
      USA. Electronic address: brown1@mail.etsu.edu.
LA  - eng
PT  - Journal Article
DEP - 20140715
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 207ZZ9QZ49 (Methylphenidate)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Corpus Striatum/*drug effects/*metabolism
MH  - Female
MH  - Glial Cell Line-Derived Neurotrophic Factor/*metabolism
MH  - Male
MH  - Methylphenidate/*pharmacology
MH  - Motor Activity/drug effects
MH  - Rats
MH  - Sex Factors
OTO - NOTNLM
OT  - Adolescence
OT  - Brain-derived neurotrophic factor
OT  - Glial-cell derived neurotrophic factor
OT  - Methylphenidate
OT  - Sensitization
EDAT- 2014/07/19 06:00
MHDA- 2015/05/12 06:00
CRDT- 2014/07/19 06:00
PHST- 2014/04/10 00:00 [received]
PHST- 2014/07/03 00:00 [revised]
PHST- 2014/07/08 00:00 [accepted]
PHST- 2014/07/19 06:00 [entrez]
PHST- 2014/07/19 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
AID - S0166-4328(14)00454-9 [pii]
AID - 10.1016/j.bbr.2014.07.014 [doi]
PST - ppublish
SO  - Behav Brain Res. 2014 Oct 15;273:139-43. doi: 10.1016/j.bbr.2014.07.014. Epub 
      2014 Jul 15.