PMID- 25037753
OWN - NLM
STAT- MEDLINE
DCOM- 20150326
LR  - 20190221
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 121
IP  - 11
DP  - 2014 Nov
TI  - Microstructure of the optic disc pit in open-angle glaucoma.
PG  - 2098-2106.e2
LID - S0161-6420(14)00506-5 [pii]
LID - 10.1016/j.ophtha.2014.06.005 [doi]
AB  - PURPOSE: To investigate the structural and clinical characteristics of the optic 
      disc pit (ODP) in primary open-angle glaucoma (POAG) via enhanced depth imaging 
      (EDI) spectral-domain optical coherence tomography (SD-OCT). DESIGN: Prospective, 
      observational case series. PARTICIPANTS: Seventy POAG eyes clinically diagnosed 
      with an ODP via stereo disc photography. METHODS: Optic discs were scanned using 
      EDI SD-OCT. Serial horizontal and vertical B-scan images covering the optic discs 
      were obtained from each eye. The structural characteristics of the ODP were 
      investigated via 3-dimensional images constructed from the serial B-scans, 
      focusing on the presence of alterations in the contour of the lamina cribrosa 
      (LC) or prelaminar tissue (PLT), in conjunction with associated clinical 
      characteristics. MAIN OUTCOME MEASURES: The structural characteristics of the ODP 
      and associated clinical characteristics. RESULTS: In the EDI SD-OCT images, the 
      ODP was viewed as an isolated alteration of the LC (n = 14, 20.0%) or PLT (n = 
      16, 22.9%) or an alteration of both the LC and PLT (n = 40, 57.1%). Alterations 
      of the LC were located at the mid-periphery near the LC insertion (n = 17) or far 
      periphery adjacent to the LC insertion (n = 37), and the depth of alteration was 
      deep (n = 23), involving nearly full-thickness LC, or shallow (n = 31), with 
      partially visible LC at the base. Fifty-four eyes (77.1%) exhibited parafoveal 
      visual field (VF) defect within 10 degrees of fixation, and in 98.1% of these 
      eyes (53/54) it was spatially associated with the location of ODP. The parafoveal 
      VF defect was more prevalent in eyes with LC alteration than those without (83.3% 
      vs. 56.2%, P = 0.023) and in eyes with deep LC defect than those with shallow 
      defect (95.7% vs. 74.2%, P = 0.036). Disc hemorrhage (32.4% vs. 0.0%, P = 0.008) 
      and peripapillary retinoschisis (18.9 vs. 0.0%, P = 0.055) were more strongly 
      associated with LC alterations located at the far periphery than at the 
      mid-periphery. CONCLUSIONS: Enhanced depth imaging SD-OCT facilitated 
      visualization of the varied structure of the ODP, which presented as alteration 
      of the LC or PLT or both. The clinical significance of differing characteristics 
      of ODP microstructure remains to be determined.
CI  - Copyright (c) 2014 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Choi, Yun Jeong
AU  - Choi YJ
AD  - Department of Ophthalmology, Seoul National University College of Medicine, Seoul 
      National University Bundang Hospital, Seongnam, Korea.
FAU - Lee, Eun Ji
AU  - Lee EJ
AD  - Department of Ophthalmology, Seoul National University College of Medicine, Seoul 
      National University Bundang Hospital, Seongnam, Korea. Electronic address: 
      opticdisc@gmail.com.
FAU - Kim, Bo Hyuk
AU  - Kim BH
AD  - Department of Ophthalmology, Seoul National University College of Medicine, Seoul 
      National University Hospital, Seoul, Korea.
FAU - Kim, Tae-Woo
AU  - Kim TW
AD  - Department of Ophthalmology, Seoul National University College of Medicine, Seoul 
      National University Bundang Hospital, Seongnam, Korea.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20140715
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Glaucoma, Open-Angle/*diagnosis
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Optic Disk/*pathology
MH  - Optic Nerve Diseases/*diagnosis
MH  - Prospective Studies
MH  - Tomography, Optical Coherence
MH  - Vision Disorders/diagnosis
MH  - Visual Fields
MH  - Young Adult
EDAT- 2014/07/20 06:00
MHDA- 2015/03/27 06:00
CRDT- 2014/07/20 06:00
PHST- 2014/01/24 00:00 [received]
PHST- 2014/03/10 00:00 [revised]
PHST- 2014/06/03 00:00 [accepted]
PHST- 2014/07/20 06:00 [entrez]
PHST- 2014/07/20 06:00 [pubmed]
PHST- 2015/03/27 06:00 [medline]
AID - S0161-6420(14)00506-5 [pii]
AID - 10.1016/j.ophtha.2014.06.005 [doi]
PST - ppublish
SO  - Ophthalmology. 2014 Nov;121(11):2098-2106.e2. doi: 10.1016/j.ophtha.2014.06.005. 
      Epub 2014 Jul 15.