PMID- 25040466
OWN - NLM
STAT- MEDLINE
DCOM- 20160601
LR  - 20181202
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 22
IP  - 10
DP  - 2015 Oct
TI  - Psychological and cognitive impairment of long-term migrators to high altitudes 
      and the relationship to physiological and biochemical changes.
PG  - 1363-9
LID - 10.1111/ene.12507 [doi]
AB  - BACKGROUND AND PURPOSE: The present study aimed to examine how long-term 
      migration to high-altitude regions affects mentality and cognition, and the 
      correlation with various physiological and biochemical changes. METHODS: The WHO 
      Neurobehavioral Core Test Battery, Raven's Standard Progressive Matrices (RSPM) 
      and Pittsburgh Sleep Quality Index questionnaire were used to assess 141 young 
      male subjects who lived in plain regions and 217 young male subjects who had 
      migrated to a 4500 m high-altitude region and lived there for 1-5 years. Arterial 
      oxyhemoglobin saturation, cerebral tissue oxygenation indices (TOIs), serum S100B 
      and brain-derived neurotrophic factor (BDNF) were also measured. RESULTS: 
      Long-term migrators to a high-altitude region exhibited exacerbated mood 
      disorders, retarded color discrimination ability, decreased visual memory 
      capacity, and impaired perceptual motor skill and motion stability. In addition, 
      the migrators exhibited lower RSPM scores and lower sleep quality. Further 
      analyses revealed significant correlations between sleep quality and cerebral 
      TOIs, mood and sleep quality, mood and certain cognitive functions, mood and 
      serum BDNF levels, and RSPM scores and serum S100B levels. CONCLUSIONS: Long-term 
      living at high altitudes causes significant impairment of psychological and 
      cognitive function. Cerebral hypoxic extent, sleep quality and biochemical 
      dysfunction are major influencing factors.
CI  - (c) 2014 EAN.
FAU - Gao, Y-X
AU  - Gao YX
AD  - Department of Neurobiology, College of Basic Medical Science, Third Military 
      Medical University, Chongqing, China.
AD  - Chongqing Key Laboratory of Neurobiology, Third Military Medical University, 
      Chongqing, China.
FAU - Li, P
AU  - Li P
AD  - Department of High Altitude Hygiene, College of High Altitude Medicine, Third 
      Military Medical University, Chongqing, China.
AD  - Key Laboratory of High Altitude Medicine, Ministry of Education, Chongqing, 
      China.
FAU - Jiang, C-H
AU  - Jiang CH
AD  - Key Laboratory of High Altitude Medicine, Ministry of Education, Chongqing, 
      China.
AD  - Department of Pathophysiology and High Altitude Physiology, College of High 
      Altitude Medicine, Third Military Medical University, Chongqing, China.
FAU - Liu, C
AU  - Liu C
AD  - Key Laboratory of High Altitude Medicine, Ministry of Education, Chongqing, 
      China.
AD  - Department of Pathophysiology and High Altitude Physiology, College of High 
      Altitude Medicine, Third Military Medical University, Chongqing, China.
FAU - Chen, Y
AU  - Chen Y
AD  - Key Laboratory of High Altitude Medicine, Ministry of Education, Chongqing, 
      China.
AD  - Department of Pathophysiology and High Altitude Physiology, College of High 
      Altitude Medicine, Third Military Medical University, Chongqing, China.
FAU - Chen, L
AU  - Chen L
AD  - Key Laboratory of High Altitude Medicine, Ministry of Education, Chongqing, 
      China.
AD  - Department of Pathophysiology and High Altitude Physiology, College of High 
      Altitude Medicine, Third Military Medical University, Chongqing, China.
FAU - Ruan, H-Z
AU  - Ruan HZ
AD  - Department of Neurobiology, College of Basic Medical Science, Third Military 
      Medical University, Chongqing, China.
AD  - Chongqing Key Laboratory of Neurobiology, Third Military Medical University, 
      Chongqing, China.
FAU - Gao, Y-Q
AU  - Gao YQ
AD  - Key Laboratory of High Altitude Medicine, Ministry of Education, Chongqing, 
      China.
AD  - Department of Pathophysiology and High Altitude Physiology, College of High 
      Altitude Medicine, Third Military Medical University, Chongqing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140707
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
SB  - IM
MH  - Adult
MH  - *Altitude
MH  - *Cognition Disorders/blood/etiology/physiopathology
MH  - Humans
MH  - *Hypoxia/blood/etiology/physiopathology
MH  - Male
MH  - Neuropsychological Tests
MH  - Tibet
MH  - *Transients and Migrants/psychology
MH  - Young Adult
OTO - NOTNLM
OT  - chronic hypoxia
OT  - cognitive ability
OT  - high-altitude migrants
OT  - psychological change
EDAT- 2014/07/22 06:00
MHDA- 2016/06/02 06:00
CRDT- 2014/07/22 06:00
PHST- 2014/02/09 00:00 [received]
PHST- 2014/05/26 00:00 [accepted]
PHST- 2014/07/22 06:00 [entrez]
PHST- 2014/07/22 06:00 [pubmed]
PHST- 2016/06/02 06:00 [medline]
AID - 10.1111/ene.12507 [doi]
PST - ppublish
SO  - Eur J Neurol. 2015 Oct;22(10):1363-9. doi: 10.1111/ene.12507. Epub 2014 Jul 7.