PMID- 25040479
OWN - NLM
STAT- MEDLINE
DCOM- 20160607
LR  - 20141124
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Linking)
VI  - 68
IP  - 12
DP  - 2014 Dec
TI  - Lower free testosterone level is correlated with left ventricular diastolic 
      dysfunction in asymptomatic middle-aged men with type 2 diabetes mellitus.
PG  - 1454-61
LID - 10.1111/ijcp.12481 [doi]
AB  - AIMS: Low testosterone (T) level is associated with cardiovascular risk factors. 
      However, the relationship between T level and heart function in asymptomatic men 
      with type 2 diabetes mellitus (T2DM) is unknown. METHODS: A total of 325 men were 
      recruited who had no history, symptoms, or signs of heart disease. RESULTS: T2DM 
      had significantly lower free T (FT) levels than those with normal glucose 
      metabolism (NGM) (428 +/- 38 pmol/l vs. 444 +/- 38 pmol/l, p = 0.0002), and had an 
      increased risk of LVDD (66.1% vs. 31.8%). There was a significant difference in 
      FT level between subjects with and without LVDD among those with T2DM (421 +/- 37 
      pmol/l vs. 442 +/- 40 pmol/l, p = 0.0007), but not among those with NGM (439 +/- 37 
      pmol/l vs. 447 +/- 39 pmol/l, p = 0.247) or in the group overall (426 +/- 38 pmol/l 
      vs. 445 +/- 38 pmol/l, p = 0.156). Lower FT level was significantly associated with 
      LVDD [univariate odds ratio (OR) = 0.63, p = 0.032; multivariate OR = 0.71, p = 
      0.039]. Receiver operating characteristic curve analysis of the usefulness of FT 
      level for predicting LVDD showed an area under the curve (AUC) of 0.85 for T2DM 
      (p < 0.001) and 0.66 for NGM (p < 0.05). FT level had a high predictive value for 
      LVDD in T2DM (83% for FT < 414 pmol/l), but a low predictive value in NGM (61% 
      for FT < 423 pmol/l). Comparison of the AUCs showed that FT level was more 
      strongly correlated with LVDD in T2DM than in NGM. CONCLUSIONS: Lower FT level is 
      correlated with LVDD in asymptomatic middle-aged men with T2DM.
CI  - (c) 2014 John Wiley & Sons Ltd.
FAU - Jin, Q
AU  - Jin Q
AD  - Department of Geriatrics, The Second Affiliated Hospital of Zhejiang University 
      School of Medicine, Hangzhou, Zhejiang Province, China.
FAU - Lou, Y
AU  - Lou Y
FAU - Chen, H
AU  - Chen H
FAU - Li, T
AU  - Li T
FAU - Bao, X
AU  - Bao X
FAU - Liu, Q
AU  - Liu Q
FAU - He, X
AU  - He X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140716
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
RN  - 0 (Biomarkers)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Biomarkers/*blood
MH  - Cardiomyopathies/*etiology
MH  - Diabetes Mellitus, Type 2/*complications/mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Testosterone/adverse effects/*deficiency
MH  - Ventricular Dysfunction, Left/*etiology
EDAT- 2014/07/22 06:00
MHDA- 2016/06/09 06:00
CRDT- 2014/07/22 06:00
PHST- 2014/07/22 06:00 [entrez]
PHST- 2014/07/22 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - 10.1111/ijcp.12481 [doi]
PST - ppublish
SO  - Int J Clin Pract. 2014 Dec;68(12):1454-61. doi: 10.1111/ijcp.12481. Epub 2014 Jul 
      16.