PMID- 25041243
OWN - NLM
STAT- MEDLINE
DCOM- 20160418
LR  - 20181202
IS  - 1399-5618 (Electronic)
IS  - 1398-5647 (Linking)
VI  - 17
IP  - 1
DP  - 2015 Feb
TI  - The role of brain-derived neurotrophic factor (BDNF) Val66Met genetic 
      polymorphism in bipolar disorder: a case-control study, comorbidities, and 
      meta-analysis of 16,786 subjects.
PG  - 27-38
LID - 10.1111/bdi.12227 [doi]
AB  - OBJECTIVES: The aim of this study was to evaluate the association of Val66Met 
      brain-derived neurotrophic factor (BDNF) polymorphism with bipolar disorder in 
      (i) a meta-analysis and (ii) a case-control study in a Mexican population. We 
      also investigated the possible association of this polymorphism with clinical 
      features. METHODS: We performed a keyword search of the PubMed and Web of Science 
      databases. A total of 22 studies that have investigated the association of 
      Val66Met (rs6265) with bipolar disorder were selected for inclusion and combined 
      with random effects meta-analysis, using allelic, additive, dominant, and 
      recessive models. Finally, the single nucleotide polymorphism (rs6265) Val66Met 
      in the BDNF gene was genotyped and compared between 139 patients with bipolar 
      disorder and 141 healthy volunteers in a Mexican population. RESULTS: The pooled 
      results from the meta-analysis (9,349 cases and 7,437 controls) did not show a 
      significant association in any of the models. The same results were obtained in 
      our case-control study when analyzing the distribution of the genotypic 
      frequencies of the Val66Met polymorphism in patients with bipolar disorder. 
      However, when we analyzed the association between rs6265 and lifetime history of 
      suicidal behavior, we found an association between genotype Val-Val and suicide 
      attempt (p = 0.02). CONCLUSIONS: Although the present study has some limitations, 
      the results indicate a lack of association between the Val66Met polymorphism and 
      bipolar disorder. However, in our case-control study in a Mexican population, the 
      Val66Met polymorphism was associated with suicidal behavior in patients with 
      bipolar disorder. Nevertheless, it is important to consider potential 
      interactions of the BDNF gene, the environment, and different inheritance 
      patterns, when carrying out future genetic studies with larger samples.
CI  - (c) 2014 The Authors. Bipolar Disorders Published by John Wiley & Sons Ltd.
FAU - Gonzalez-Castro, Thelma Beatriz
AU  - Gonzalez-Castro TB
AD  - Division Academica de Ciencias de la Salud, Universidad Juarez Autonoma de 
      Tabasco, Villahermosa, Tabasco.
FAU - Nicolini, Humberto
AU  - Nicolini H
FAU - Lanzagorta, Nuria
AU  - Lanzagorta N
FAU - Lopez-Narvaez, Lilia
AU  - Lopez-Narvaez L
FAU - Genis, Alma
AU  - Genis A
FAU - Pool Garcia, Sherezada
AU  - Pool Garcia S
FAU - Tovilla-Zarate, Carlos Alfonso
AU  - Tovilla-Zarate CA
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20140708
PL  - Denmark
TA  - Bipolar Disord
JT  - Bipolar disorders
JID - 100883596
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dipeptides)
RN  - 3918-94-3 (valylvaline)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/epidemiology/*genetics/psychology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Dipeptides/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Mexico/epidemiology
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Suicide/*psychology/statistics & numerical data
OTO - NOTNLM
OT  - Mexican population
OT  - bipolar disorder
OT  - brain-derived neurotrophic factor (BDNF) gene
OT  - meta-analysis
EDAT- 2014/07/22 06:00
MHDA- 2016/04/19 06:00
CRDT- 2014/07/22 06:00
PHST- 2013/06/05 00:00 [received]
PHST- 2013/12/20 00:00 [accepted]
PHST- 2014/07/22 06:00 [entrez]
PHST- 2014/07/22 06:00 [pubmed]
PHST- 2016/04/19 06:00 [medline]
AID - 10.1111/bdi.12227 [doi]
PST - ppublish
SO  - Bipolar Disord. 2015 Feb;17(1):27-38. doi: 10.1111/bdi.12227. Epub 2014 Jul 8.