PMID- 25041363
OWN - NLM
STAT- MEDLINE
DCOM- 20150629
LR  - 20141007
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 40
IP  - 7
DP  - 2014 Oct
TI  - Activation-induced cytidine deaminase regulates activity-dependent BDNF 
      expression in post-mitotic cortical neurons.
PG  - 3032-9
LID - 10.1111/ejn.12678 [doi]
AB  - Activity-dependent gene expression depends, in part, on transcriptional 
      regulation that is coordinated by rapid changes in the chromatin landscape as 
      well as the covalent modification of DNA. Here we demonstrate that the expression 
      of brain-derived neurotrophic factor (BDNF), a gene that is critically involved 
      in neural plasticity and subject to epigenetic regulation, is regulated by the 
      RNA/DNA editing enzyme, activation-induced cytidine deaminase (AID). Similar to 
      previous reports, we observed an activity-dependent induction of BDNF exon IV 
      mRNA expression, which correlated with a reduction in DNA methylation within the 
      BDNF P4 promoter. Lentiviral-mediated knockdown of AID disrupted these effects 
      and inhibited BDNF exon IV mRNA expression, an effect that was associated with 
      decreased cAMP response element-binding protein occupancy within the BDNF P4 
      promoter. Thus, together with other epigenetic mechanisms, AID plays a key role 
      in regulating activity-dependent BDNF expression in post-mitotic cortical 
      neurons.
CI  - (c) 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - Ratnu, Vikram S
AU  - Ratnu VS
AD  - Psychiatric Epigenomics Laboratory, Queensland Brain Institute, The University of 
      Queensland, Brisbane, Qld, 4072, Australia.
FAU - Wei, Wei
AU  - Wei W
FAU - Bredy, Timothy W
AU  - Bredy TW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140717
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (RNA, Messenger)
RN  - EC 3.5.4.- (AICDA (activation-induced cytidine deaminase))
RN  - EC 3.5.4.5 (Cytidine Deaminase)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cerebral Cortex/*metabolism
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Cytidine Deaminase/*genetics
MH  - DNA Methylation
MH  - *Gene Expression Regulation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mitosis
MH  - Neurons/*metabolism
MH  - RNA, Messenger/metabolism
OTO - NOTNLM
OT  - AID
OT  - BDNF
OT  - DNA methylation
OT  - mice
OT  - post-mitotic cortical neurons
EDAT- 2014/07/22 06:00
MHDA- 2015/06/30 06:00
CRDT- 2014/07/22 06:00
PHST- 2014/02/14 00:00 [received]
PHST- 2014/06/11 00:00 [revised]
PHST- 2014/06/16 00:00 [accepted]
PHST- 2014/07/22 06:00 [entrez]
PHST- 2014/07/22 06:00 [pubmed]
PHST- 2015/06/30 06:00 [medline]
AID - 10.1111/ejn.12678 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2014 Oct;40(7):3032-9. doi: 10.1111/ejn.12678. Epub 2014 Jul 17.