PMID- 25041504
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20161125
IS  - 1440-1797 (Electronic)
IS  - 1320-5358 (Linking)
VI  - 19
IP  - 10
DP  - 2014 Oct
TI  - Polymorphisms in oxidative stress pathway genes and risk of diabetic nephropathy 
      in South Indian type 2 diabetic patients.
PG  - 623-9
LID - 10.1111/nep.12293 [doi]
AB  - AIM: Diabetic nephropathy (DN), a common microvascular complication of type 2 
      diabetes mellitus (T2DM) is polygenic, with a vast array of genes contributing to 
      disease susceptibility. Accordingly, we explored the association between DN and 
      six polymorphisms in oxidative stress related genes, namely eNOS, p22phox subunit 
      of NAD(P)H oxidase, PARP-1 and XRCC1 in South Indian T2DM subjects. METHODS: The 
      study included 155 T2DM subjects with DN and 162 T2DM patients with no evidence 
      of DN. The selected polymorphisms were genotyped by polymerase chain reaction and 
      Taqman allele discrimination assay. RESULTS: No significant difference was 
      observed in the genotype and allele distribution of eNOS -786T > C, intron 4a4b, 
      p22phox 242C > T and XRCC1 Arg399Gln polymorphisms between T2DM groups with and 
      without DN. Contrastingly, there appeared to be a significant association of eNOS 
      894G > T and PARP-1 Val762Ala polymorphisms with DN wherein, the presence of 894T 
      allele was associated with an enhanced risk for DN [P = 0.005; OR = 1.78 
      (1.17-2.7)], while the 762Ala allele seemed to confer significant protection 
      against DN [P = 0.02; OR = 0.59 (0.37-0.92)]. Multiple logistic regression 
      analysis revealed a significant and independent association of eNOS 894G > T, 
      PARP-1 Val762Ala polymorphisms and hypertension with DN in T2DM individuals. 
      CONCLUSIONS: eNOS 894G > T and PARP-1 Val762Ala polymorphisms appeared to 
      associate significantly with DN, with the former contributing to an enhanced risk 
      and the latter to a reduced susceptibility to DN in South Indian T2DM 
      individuals.
CI  - (c) 2014 Asian Pacific Society of Nephrology.
FAU - Narne, Parimala
AU  - Narne P
AD  - Department of Genetics, Osmania University, Hyderabad, India.
FAU - Ponnaluri, Kamakshi Chaithri
AU  - Ponnaluri KC
FAU - Siraj, Mohammed
AU  - Siraj M
FAU - Ishaq, Mohammed
AU  - Ishaq M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Nephrology (Carlton)
JT  - Nephrology (Carlton, Vic.)
JID - 9615568
RN  - EC 1.14.13.39 (NOS3 protein, human)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
RN  - EC 2.4.2.30 (PARP1 protein, human)
RN  - EC 2.4.2.30 (Poly (ADP-Ribose) Polymerase-1)
RN  - EC 2.4.2.30 (Poly(ADP-ribose) Polymerases)
SB  - IM
MH  - Aged
MH  - Chi-Square Distribution
MH  - Diabetes Mellitus, Type 2/diagnosis/ethnology/*genetics
MH  - Diabetic Nephropathies/diagnosis/ethnology/*genetics/prevention & control
MH  - Disease Progression
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - India/epidemiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Nitric Oxide Synthase Type III/genetics
MH  - Odds Ratio
MH  - Oxidative Stress/*genetics
MH  - Phenotype
MH  - Poly (ADP-Ribose) Polymerase-1
MH  - Poly(ADP-ribose) Polymerases/genetics
MH  - *Polymorphism, Genetic
MH  - Protective Factors
MH  - Risk Factors
OTO - NOTNLM
OT  - diabetic nephropathy
OT  - oxidative stress
OT  - polymorphism
OT  - type 2 diabetes mellitus
EDAT- 2014/07/22 06:00
MHDA- 2015/06/16 06:00
CRDT- 2014/07/22 06:00
PHST- 2014/06/11 00:00 [accepted]
PHST- 2014/07/22 06:00 [entrez]
PHST- 2014/07/22 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
AID - 10.1111/nep.12293 [doi]
PST - ppublish
SO  - Nephrology (Carlton). 2014 Oct;19(10):623-9. doi: 10.1111/nep.12293.