PMID- 25042995
OWN - NLM
STAT- MEDLINE
DCOM- 20151006
LR  - 20150205
IS  - 1097-0010 (Electronic)
IS  - 0022-5142 (Linking)
VI  - 95
IP  - 4
DP  - 2015 Mar 15
TI  - Effects of combined therapy with glipizide and Aralia root bark extract on 
      glycemic control and lipid profiles in patients with type 2 diabetes mellitus.
PG  - 739-44
LID - 10.1002/jsfa.6829 [doi]
AB  - BACKGROUND: The root bark of Aralia is a rich source of bioactive components that 
      may improve glycemic control and lipid status. In this study, 148 patients with 
      type 2 diabetes mellitus (T2DM) were assigned randomly to receive either 
      glipizide alone or glipizide plus Aralia root bark extract (ARBE) for 8 weeks to 
      test the effects of ARBE plus glipizide therapy on glycemic control and lipid 
      profiles in these patients. RESULTS: Levels of HbA1c, fasting plasma glucose 
      (FPG) and 2 h postprandial plasma glucose (2-h PPG) in both groups significantly 
      decreased from baseline. Glycated hemoglobin (HbA1c) decreased marginally 
      significantly in participants taking glipizide plus ARBE compared with the 
      glipizide group (P = 0.06). Participants in the combination group had significant 
      decreases in total cholesterol (TC) and low-density lipoprotein cholesterol 
      (LDL-C), and the between-group difference achieved statistical significance for 
      LDL-C (P = 0.04). Reduction in HbA1c in the combination group was significantly 
      associated with changes in TC (r = 0.32; P = 0.006) and LDL-C (r = 0.34; P = 
      0.005), and the change in FPG was inversely correlated with LDL-C reduction (r = 
      0.34; P = 0.004). CONCLUSIONS: In patients with T2DM, combination therapy with 
      glipizide and ARBE resulted in moderately lowering HbA1c and LDL-C levels 
      compared with glipizide alone.
CI  - (c) 2014 Society of Chemical Industry.
FAU - Liu, Xiao-Hong
AU  - Liu XH
AD  - The First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, 277 
      Yanta West Road, Xi'an, Shaanxi, 710061, China.
FAU - Li, Xing-Min
AU  - Li XM
FAU - Han, Cheng-Cheng
AU  - Han CC
FAU - Fang, Xiang-Feng
AU  - Fang XF
FAU - Ma, Le
AU  - Ma L
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140822
PL  - England
TA  - J Sci Food Agric
JT  - Journal of the science of food and agriculture
JID - 0376334
RN  - 0 (Antioxidants)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Hypolipidemic Agents)
RN  - 0 (Plant Extracts)
RN  - X7WDT95N5C (Glipizide)
SB  - IM
MH  - Antioxidants/adverse effects/*therapeutic use
MH  - Aralia/*chemistry
MH  - China
MH  - Combined Modality Therapy/adverse effects
MH  - Diabetes Mellitus, Type 2/blood/complications/*diet therapy/drug therapy
MH  - *Dietary Supplements/adverse effects
MH  - Double-Blind Method
MH  - Female
MH  - Glipizide/therapeutic use
MH  - Humans
MH  - Hyperglycemia/prevention & control
MH  - Hyperlipidemias/complications/prevention & control
MH  - Hypoglycemic Agents/therapeutic use
MH  - Hypolipidemic Agents/adverse effects/*therapeutic use
MH  - Intention to Treat Analysis
MH  - Lost to Follow-Up
MH  - Male
MH  - Middle Aged
MH  - Patient Dropouts
MH  - Plant Bark/*chemistry
MH  - Plant Extracts/adverse effects/*therapeutic use
OTO - NOTNLM
OT  - Aralia
OT  - antioxidants
OT  - glycemic control
OT  - lipid status
OT  - type 2 diabetes mellitus
EDAT- 2014/07/22 06:00
MHDA- 2015/10/07 06:00
CRDT- 2014/07/22 06:00
PHST- 2013/09/26 00:00 [received]
PHST- 2014/06/02 00:00 [revised]
PHST- 2014/07/14 00:00 [accepted]
PHST- 2014/07/22 06:00 [entrez]
PHST- 2014/07/22 06:00 [pubmed]
PHST- 2015/10/07 06:00 [medline]
AID - 10.1002/jsfa.6829 [doi]
PST - ppublish
SO  - J Sci Food Agric. 2015 Mar 15;95(4):739-44. doi: 10.1002/jsfa.6829. Epub 2014 Aug 
      22.