PMID- 25043076 OWN - NLM STAT- MEDLINE DCOM- 20150409 LR - 20140721 IS - 2542-5641 (Electronic) IS - 0366-6999 (Linking) VI - 127 IP - 14 DP - 2014 TI - Outcomes of peripheral blood stem cell transplantation in patients from human leukocyte antigen matched or mismatched unrelated donors. PG - 2612-7 AB - BACKGROUND: Allogeneic peripheral blood stem cell transplantation from unrelated donors (UR-PBSCT) is an alternative treatment for many hematologic diseases due to lack of human leukocyte antigen (HLA)-identical sibling donors. This study aimed to evaluate the impact of the degree of the HLA match on the clinical efficacy of UR-PBSCT. METHODS: Patients who underwent UR-PBSCT from September 2003 to September 2012 were retrospectively investigated. They were divided into three groups according to high-resolution molecular typing. SPSS version 17.0 was used to analysis and compare the statistics of engraftment, incidence of GVHD, other complications and survival among the groups. RESULTS: One hundred and eleven patients received UR-PBSCT, 60 of them with an HLA matched donor (10/10), 36 of them with a one locus mismatched donor (9/10), and 15 of them with a two loci mismatched donor (8/10). Similar basic characteristics were found in the three groups. No differences were found in engraftment of myeloid cells or platelets in the three groups (P > 0.05). Two-year cumulative incidence of relapse, overall survival (OS) and disease-free survival (DFS) among those three groups were similar (P > 0.05). The cumulative incidence of 100-day III-IV aGVHD in the HLA matched group and the one HLA locus mismatched group were significantly lower than that in the two HLA loci mismatched group (3.3%, 8.6%, and 26.7%, P = 0.009). The occurrence rate of new pulmonary infections in the HLA matched group was lower than in the two HLA mismatched groups (26.67%, 52.78%, and 41.18%, P = 0.035). The cumulative incidence of 100-day and 2-year transplantation related mortality (TRM) in two HLA loci mismatched group was higher than in the HLA matched group and in the one HLA locus mismatched group, (8.4%, 11.8% and 33.3%, P = 0.016) and (12.3%, 18.7% and 47.5%, P = 0.002). CONCLUSIONS: HLA mismatch will not significantly impact the engraftment or 2-year survival after UR-PBSCT, but two mismatched HLA loci may increase the cumulative incidence of severe aGVHD and TRM. FAU - Cao, Tingting AU - Cao T AD - Department of Hematology, Chinese People's Liberation Army General Hospital, Beijing 100853, China; Department of Hematology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, China. FAU - Li, Yanfen AU - Li Y AD - Department of Hematology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. FAU - Wang, Quanshun AU - Wang Q AD - Department of Hematology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. FAU - Li, Honghua AU - Li H AD - Department of Hematology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. FAU - Bo, Jian AU - Bo J AD - Department of Hematology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. FAU - Zhao, Yu AU - Zhao Y AD - Department of Hematology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. FAU - Jing, Yu AU - Jing Y AD - Department of Hematology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. FAU - Wang, Shuhong AU - Wang S AD - Department of Hematology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. FAU - Zhu, Haiyan AU - Zhu H AD - Department of Hematology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. FAU - Dou, Liping AU - Dou L AD - Department of Hematology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. FAU - Jia, Bojun AU - Jia B AD - Department of Hematology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. FAU - Gao, Chunji AU - Gao C AD - Department of Hematology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. FAU - Yu, Li AU - Yu L AD - Department of Hematology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. FAU - Huang, Wenrong AU - Huang W AD - Department of Hematology, Chinese People's Liberation Army General Hospital, Beijing 100853, China; Department of Hematology, Hainan Branch of Chinese People's Liberation Army General Hospital, Linwang Street of Sanya City, Hainan 572013, China. Email: huangwr301@163.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - China TA - Chin Med J (Engl) JT - Chinese medical journal JID - 7513795 RN - 0 (HLA Antigens) SB - IM MH - Adolescent MH - Adult MH - Child MH - Female MH - HLA Antigens/*immunology MH - Humans MH - Male MH - Middle Aged MH - Peripheral Blood Stem Cell Transplantation/*standards MH - *Unrelated Donors MH - Young Adult EDAT- 2014/07/22 06:00 MHDA- 2015/04/10 06:00 CRDT- 2014/07/22 06:00 PHST- 2014/07/22 06:00 [entrez] PHST- 2014/07/22 06:00 [pubmed] PHST- 2015/04/10 06:00 [medline] PST - ppublish SO - Chin Med J (Engl). 2014;127(14):2612-7.