PMID- 25043086
OWN - NLM
STAT- MEDLINE
DCOM- 20150409
LR  - 20190816
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 127
IP  - 14
DP  - 2014
TI  - Prognostic significance of gamma-H2AX in laryngeal squamous cell carcinoma after 
      surgery.
PG  - 2664-7
AB  - BACKGROUND: The clinical significance of gamma-H2AX in laryngeal squamous cell 
      carcinoma (LSCC) has not yet been established. This study was performed to assess 
      the expression of nuclear gamma-H2AX in benign and malignant laryngeal lesions and to 
      assess its clinicopathological significance. METHODS: A total of 70 LSCC 
      tumor-normal tissue paired samples were evaluated for gamma-H2AX expression using 
      immunohistochemical staining. Their expression was correlated with different 
      clinicopathological parameters. RESULTS: Nuclear gamma-H2AX expression was frequently 
      detected in LSCC tissues (P < 0.001). High nuclear gamma-H2AX levels were not 
      associated with any clinicopathological characteristics of LSCC (P > 0.05). 
      Univariate Kaplan-Meier analysis showed that positive nuclear gamma-H2AX expression 
      was associated with a decreased overall survival (P = 0.017). Multivariate Cox 
      regression analysis showed that nuclear gamma-H2AX expression was an independent risk 
      factor for overall survival. CONCLUSION: The expression of nuclear gamma-H2AX might 
      be closely related to the prognosis of LSCC.
FAU - Zhang, Jingyi
AU  - Zhang J
AD  - Department of ENT, Eye, Ear, Nose & Throat Hospital, Fudan University, Shanghai 
      200437, China.
FAU - Cheng, Lei
AU  - Cheng L
AD  - Department of ENT, Eye, Ear, Nose & Throat Hospital, Fudan University, Shanghai 
      200437, China.
FAU - Zhou, Liang
AU  - Zhou L
AD  - Department of ENT, Eye, Ear, Nose & Throat Hospital, Fudan University, Shanghai 
      200437, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (H2AX protein, human)
RN  - 0 (Histones)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism/*pathology/surgery
MH  - Female
MH  - Head and Neck Neoplasms/*metabolism/*pathology/surgery
MH  - Histones/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*diagnosis/metabolism/*pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Squamous Cell Carcinoma of Head and Neck
EDAT- 2014/07/22 06:00
MHDA- 2015/04/10 06:00
CRDT- 2014/07/22 06:00
PHST- 2014/07/22 06:00 [entrez]
PHST- 2014/07/22 06:00 [pubmed]
PHST- 2015/04/10 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2014;127(14):2664-7.