PMID- 25043449
OWN - NLM
STAT- MEDLINE
DCOM- 20150512
LR  - 20211021
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Print)
IS  - 0361-9230 (Linking)
VI  - 107
DP  - 2014 Aug
TI  - Eating habits modulate short term memory and epigenetical regulation of brain 
      derived neurotrophic factor in hippocampus of low- and high running capacity 
      rats.
PG  - 54-60
LID - S0361-9230(14)00105-1 [pii]
LID - 10.1016/j.brainresbull.2014.07.003 [doi]
AB  - Exercise capacity and dietary restriction (DR) are linked to improved quality of 
      life, including enhanced brain function and neuro-protection. Brain derived 
      neurotrophic factor (BDNF) is one of the key proteins involved in the beneficial 
      effects of exercise on brain. Low capacity runner (LCR) and high capacity runner 
      (HCR) rats were subjected to DR in order to investigate the regulation of BDNF. 
      HCR-DR rats out-performed other groups in a passive avoidance test. BDNF content 
      increased significantly in the hippocampus of HCR-DR groups compared to control 
      groups (p<0.05). The acetylation of H3 increased significantly only in the LCR-DR 
      group. However, chip-assay revealed that the specific binding between acetylated 
      histone H3 and BNDF promoter was increased in both LCR-DR and HCR-DR groups. In 
      spite of these increases in binding, at the transcriptional level only, the 
      LCR-DR group showed an increase in BDNF mRNA content. Additionally, DR also 
      induced the activity of cAMP response element-binding protein (CREB), while the 
      content of SIRT1 was not altered. Peroxisome proliferator-activated receptor 
      gamma coactivator-1 alpha (PGC-1alpha) was elevated in HCR-DR groups. But, based on 
      the levels of nuclear respiratory factor-1 and cytocrome c oxidase, it appears 
      that DR did not cause mitochondrial biogenesis. The data suggest that DR-mediated 
      induction of BDNF levels includes chromatin remodeling. Moreover, DR does not 
      induce mitochondrial biogenesis in the hippocampus of LCR/HCR rats. DR results in 
      different responses to a passive avoidance test, and BDNF regulation in LCR and 
      HCR rats.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Torma, Ferenc
AU  - Torma F
AD  - Research Institute of Sport Science, Semmelweis University, Budapest, Hungary.
FAU - Bori, Zoltan
AU  - Bori Z
AD  - Research Institute of Sport Science, Semmelweis University, Budapest, Hungary.
FAU - Koltai, Erika
AU  - Koltai E
AD  - Research Institute of Sport Science, Semmelweis University, Budapest, Hungary.
FAU - Felszeghy, Klara
AU  - Felszeghy K
AD  - Research Institute of Sport Science, Semmelweis University, Budapest, Hungary.
FAU - Vacz, Gabriella
AU  - Vacz G
AD  - Research Institute of Sport Science, Semmelweis University, Budapest, Hungary.
FAU - Koch, Lauren
AU  - Koch L
AD  - Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, 
      MI, USA.
FAU - Britton, Steven
AU  - Britton S
AD  - Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, 
      MI, USA.
FAU - Boldogh, Istvan
AU  - Boldogh I
AD  - Department of Microbiology and Immunology, University of Texas Medical Branch at 
      Galveston, Galveston, TX 77555, USA.
FAU - Radak, Zsolt
AU  - Radak Z
AD  - Research Institute of Sport Science, Semmelweis University, Budapest, Hungary. 
      Electronic address: radak@tf.hu.
LA  - eng
GR  - P30 DK020572/DK/NIDDK NIH HHS/United States
GR  - P30 ES006676/ES/NIEHS NIH HHS/United States
GR  - R01 DK077200/DK/NIDDK NIH HHS/United States
GR  - R24 RR017718/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140717
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Histones)
RN  - 0 (Nuclear Respiratory Factors)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Ppargc1a protein, rat)
RN  - 0 (Transcription Factors)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
RN  - EC 2.3.1.48 (Crebbp protein, rat)
RN  - EC 3.5.1.- (Sirt1 protein, rat)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - CREB-Binding Protein/metabolism
MH  - *Epigenesis, Genetic
MH  - Feeding Behavior/*physiology
MH  - Hippocampus/*metabolism
MH  - Histones/metabolism
MH  - Male
MH  - Memory, Short-Term/*physiology
MH  - Nuclear Respiratory Factors/metabolism
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
MH  - Rats
MH  - Running/*physiology
MH  - Sirtuin 1/metabolism
MH  - Transcription Factors/metabolism
PMC - PMC4152381
MID - NIHMS614963
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Dietary restriction
OT  - Epigenetics
OT  - Exercise capacity
OT  - Histone
EDAT- 2014/07/22 06:00
MHDA- 2015/05/13 06:00
PMCR- 2015/08/01
CRDT- 2014/07/22 06:00
PHST- 2014/06/16 00:00 [received]
PHST- 2014/07/07 00:00 [revised]
PHST- 2014/07/09 00:00 [accepted]
PHST- 2014/07/22 06:00 [entrez]
PHST- 2014/07/22 06:00 [pubmed]
PHST- 2015/05/13 06:00 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - S0361-9230(14)00105-1 [pii]
AID - 10.1016/j.brainresbull.2014.07.003 [doi]
PST - ppublish
SO  - Brain Res Bull. 2014 Aug;107:54-60. doi: 10.1016/j.brainresbull.2014.07.003. Epub 
      2014 Jul 17.