PMID- 25043949
OWN - NLM
STAT- MEDLINE
DCOM- 20150721
LR  - 20211203
IS  - 1098-2264 (Electronic)
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 53
IP  - 11
DP  - 2014 Nov
TI  - ZFP36-FOSB fusion defines a subset of epithelioid hemangioma with atypical 
      features.
PG  - 951-9
LID - 10.1002/gcc.22206 [doi]
AB  - Epithelioid hemangioma (EH) is a benign neoplasm with distinctive vasoformative 
      features, which occasionally shows increased cellularity, cytologic atypia, 
      and/or loco-regional aggressive growth, resulting in challenging differential 
      diagnosis from malignant vascular neoplasms. Based on two intraosseous EH index 
      cases with worrisome histologic features, such as the presence of necrosis, RNA 
      sequencing was applied for possible fusion gene discovery and potential 
      subclassification of a novel atypical EH subset. A ZFP36-FOSB fusion was detected 
      in one case, while a WWTR1-FOSB chimeric transcript in the other, both were 
      further validated by fluorescence in situ hybridization (FISH) and reverse 
      transcription polymerase chain reaction (RT-PCR). These abnormalities were then 
      screened by FISH in 44 EH from different locations with seven additional EH 
      revealing FOSB gene rearrangements, all except one being fused to ZFP36. 
      Interestingly, 4/6 penile EH studied showed FOSB abnormalities. Although certain 
      atypical histologic features were observed in the FOSB-rearranged EH, including 
      solid growth, increased cellularity, mild to moderate nuclear pleomorphism, and 
      necrosis in 3/9 cases, no overt sarcomatous areas were discerned to objectively 
      separate the lesions from the fusion-negative EH. No patient has developed 
      recurrence to date, but the follow-up was relatively limited and short to draw 
      definitive conclusions regarding behavior. Although FOSB-rearranged EH do not 
      show significant morphologic overlap with SERPINE1-FOSB fusion-positive 
      pseudomyogenic hemangioendothelioma, FOSB oncogenic activation is emerging as an 
      important event in these benign and intermediate groups of vascular tumors.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Antonescu, Cristina R
AU  - Antonescu CR
AD  - Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.
FAU - Chen, Hsiao-Wei
AU  - Chen HW
FAU - Zhang, Lei
AU  - Zhang L
FAU - Sung, Yun-Shao
AU  - Sung YS
FAU - Panicek, David
AU  - Panicek D
FAU - Agaram, Narasimhan P
AU  - Agaram NP
FAU - Dickson, Brendan C
AU  - Dickson BC
FAU - Krausz, Thomas
AU  - Krausz T
FAU - Fletcher, Christopher D
AU  - Fletcher CD
LA  - eng
GR  - P01CA47179/CA/NCI NIH HHS/United States
GR  - P50 CA 140146-01/CA/NCI NIH HHS/United States
GR  - P30 CA008748/CA/NCI NIH HHS/United States
GR  - P01 CA047179/CA/NCI NIH HHS/United States
GR  - P50 CA140146/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140718
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (FOSB protein, human)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (SERPINE1 protein, human)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Transcriptional Coactivator with PDZ-Binding Motif Proteins)
RN  - 0 (Tristetraprolin)
RN  - 0 (WWTR1 protein, human)
RN  - 0 (ZFP36 protein, human)
RN  - 0 (ZFP36-FOSB fusion protein, human)
SB  - IM
MH  - Adult
MH  - Child
MH  - Female
MH  - *Gene Fusion
MH  - Hemangioendothelioma, Epithelioid/*genetics/pathology
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/genetics
MH  - Male
MH  - Middle Aged
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Plasminogen Activator Inhibitor 1/genetics
MH  - Proto-Oncogene Proteins c-fos/*genetics
MH  - Sequence Analysis, RNA
MH  - Trans-Activators
MH  - Transcription Factors
MH  - Transcriptional Coactivator with PDZ-Binding Motif Proteins
MH  - Tristetraprolin/*genetics
MH  - Vascular Neoplasms/*genetics/pathology
PMC - PMC4229947
MID - NIHMS640230
COIS- Conflict of interest: none
EDAT- 2014/07/22 06:00
MHDA- 2015/07/22 06:00
PMCR- 2014/11/13
CRDT- 2014/07/22 06:00
PHST- 2014/06/20 00:00 [received]
PHST- 2014/07/03 00:00 [accepted]
PHST- 2014/07/22 06:00 [entrez]
PHST- 2014/07/22 06:00 [pubmed]
PHST- 2015/07/22 06:00 [medline]
PHST- 2014/11/13 00:00 [pmc-release]
AID - 10.1002/gcc.22206 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 2014 Nov;53(11):951-9. doi: 10.1002/gcc.22206. Epub 
      2014 Jul 18.