PMID- 25044977
OWN - NLM
STAT- MEDLINE
DCOM- 20150713
LR  - 20211021
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 35
IP  - 12
DP  - 2014 Dec
TI  - BDNF Val66Met genotype interacts with childhood adversity and influences the 
      formation of hippocampal subfields.
PG  - 5776-83
LID - 10.1002/hbm.22584 [doi]
AB  - Childhood stress and genetic factors like the Val66MET polymorphism of the brain 
      derived neurotrophic factor (BDNF) gene are associated with a higher risk for 
      developing major depressive disorder (MDD) and might also influence hippocampal 
      changes. The aim of this study was to determine which hippocampal dentate gyrus 
      and cornu ammonis subfields are altered in MDD compared to healthy controls and 
      which subfields are affected by the BDNF Val66Met polymorphism and child 
      adversity. Adult patients with MDD and healthy matched controls underwent 
      high-resolution magnetic resonance imaging. Automatic segmentation using the 
      programme FreeSurfer was used to segment the hippocampal subfields dentate gyrus 
      (DG/CA4), CA1 and CA2/3. The history of possible childhood adversity was assessed 
      using the Childhood Trauma Questionnaire and the Val66Met BDNF SNP (rs6265) 
      genotypes were obtained. Patients with MDD had significantly smaller CA4/DG and 
      CA2/3 volumes compared to healthy controls. Furthermore, there was a significant 
      interactive effect of BDNF allele and childhood adversity on CA2/3 and CA4/DG 
      volumes. Met allele carriers without childhood adversity had larger and with 
      childhood adversity smaller CA4/DG and CA2/3 volumes than Val-allele homozygotes. 
      Our results highlight stress by gene interactions as relevant for hippocampal 
      volume reductions, in particular for the subfield CA2/3 and dentate gyrus.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Frodl, Thomas
AU  - Frodl T
AD  - Department of Psychiatry and Institute of Neuroscience, University of Dublin, 
      Trinity College Dublin, Dublin, Ireland; Centre of Advanced Medical Imaging, St. 
      James's Hospital & Trinity College Dublin, Dublin, Ireland; Department of 
      Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
FAU - Skokauskas, Norbert
AU  - Skokauskas N
FAU - Frey, Eva-Maria
AU  - Frey EM
FAU - Morris, Derek
AU  - Morris D
FAU - Gill, Michael
AU  - Gill M
FAU - Carballedo, Angela
AU  - Carballedo A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140710
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - *Child Abuse
MH  - Depressive Disorder, Major/*pathology/physiopathology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Hippocampus/*growth & development/*pathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Organ Size
MH  - Polymorphism, Single Nucleotide
MH  - *Stress, Psychological
MH  - Surveys and Questionnaires
PMC - PMC6869047
OTO - NOTNLM
OT  - BDNF genotype
OT  - CA2/3
OT  - childhood maltreatment
OT  - dentate gyrus
OT  - depression
OT  - hippocampus
EDAT- 2014/07/22 06:00
MHDA- 2015/07/15 06:00
PMCR- 2014/07/10
CRDT- 2014/07/22 06:00
PHST- 2014/02/19 00:00 [received]
PHST- 2014/06/05 00:00 [revised]
PHST- 2014/07/02 00:00 [accepted]
PHST- 2014/07/22 06:00 [entrez]
PHST- 2014/07/22 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
PHST- 2014/07/10 00:00 [pmc-release]
AID - HBM22584 [pii]
AID - 10.1002/hbm.22584 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2014 Dec;35(12):5776-83. doi: 10.1002/hbm.22584. Epub 2014 Jul 
      10.