PMID- 25045081
OWN - NLM
STAT- MEDLINE
DCOM- 20160125
LR  - 20200930
IS  - 1552-4981 (Electronic)
IS  - 1552-4973 (Linking)
VI  - 103
IP  - 4
DP  - 2015 May
TI  - Effects of epigallocatechin-3-gallate on the healing of extraction sockets with a 
      periapical lesion: A pilot study in dogs.
PG  - 727-34
LID - 10.1002/jbm.b.33238 [doi]
AB  - The aim of this study was to characterize the healing process of extraction 
      sockets with a periapical lesion following immediate graft with collagenated 
      bovine bone mineral (CBBM) soaked with epigallocatechin-3-gallate (EGCG). 
      Following induction of periapical lesions in premolars in five dogs, treatment of 
      extraction sockets was divided into three groups: control (no treatment) and two 
      test groups, CBBM with or without EGCG. 3D reconstruction and superimposition of 
      the digital images were used to measure the dimensional changes in alveolar 
      ridge. Histologic specimen was evaluated in all groups. The horizontal ridge 
      widths at 4-mm level were wider in both test groups (3.3 +/- 1.7 mm in CBBM; 
      3.0 +/- 1.7 mm in CBBM+EGCG) than in the control group (1.7 +/- 2.4 mm). Fibrosis and 
      limited new bone formation were observed in the apical regions of test groups; 
      however, the extent of fibrosis was less in the CBBM+EGCG group. Within the 
      limitations of this study, it was conjectured that adjunctive use of EGCG with 
      CBBM can be a candidate biomaterial in grafting of extraction socket with 
      periapical lesion. Bone regeneration at the coronal region of the CBBM grafted 
      socket might not be influenced by the presence of a periapical lesion.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Hong, Ji-Youn
AU  - Hong JY
AD  - Department of Periodontology, School of Dentistry, Kyung Hee University, Seoul, 
      134-727, Republic of Korea.
FAU - Yon, Jeyoung
AU  - Yon J
FAU - Lee, Jung-Seok
AU  - Lee JS
FAU - Lee, In-Kyeong
AU  - Lee IK
FAU - Yang, Cheryl
AU  - Yang C
FAU - Kim, Min-Soo
AU  - Kim MS
FAU - Choi, Seong-Ho
AU  - Choi SH
FAU - Jung, Ui-Won
AU  - Jung UW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140717
PL  - United States
TA  - J Biomed Mater Res B Appl Biomater
JT  - Journal of biomedical materials research. Part B, Applied biomaterials
JID - 101234238
RN  - 0 (Bone Substitutes)
RN  - 8R1V1STN48 (Catechin)
RN  - BQM438CTEL (epigallocatechin gallate)
SB  - IM
MH  - Animals
MH  - Bone Regeneration/*drug effects
MH  - Bone Substitutes/*pharmacology
MH  - Catechin/*analogs & derivatives/pharmacology
MH  - Cattle
MH  - Dogs
MH  - Male
MH  - Orbit/*injuries
MH  - Pilot Projects
OTO - NOTNLM
OT  - bio-oss collagen
OT  - epigallocatechin gallate
OT  - histology
OT  - periapical periodontitis
OT  - tooth extraction
EDAT- 2014/07/22 06:00
MHDA- 2016/01/26 06:00
CRDT- 2014/07/22 06:00
PHST- 2014/02/06 00:00 [received]
PHST- 2014/05/29 00:00 [revised]
PHST- 2014/06/05 00:00 [accepted]
PHST- 2014/07/22 06:00 [entrez]
PHST- 2014/07/22 06:00 [pubmed]
PHST- 2016/01/26 06:00 [medline]
AID - 10.1002/jbm.b.33238 [doi]
PST - ppublish
SO  - J Biomed Mater Res B Appl Biomater. 2015 May;103(4):727-34. doi: 
      10.1002/jbm.b.33238. Epub 2014 Jul 17.