PMID- 25045267
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140721
LR  - 20220331
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 10
DP  - 2014
TI  - Depression, 5HTTLPR and BDNF Val66Met polymorphisms, and plasma BDNF levels in 
      hemodialysis patients with chronic renal failure.
PG  - 1235-41
LID - 10.2147/NDT.S54277 [doi]
AB  - OBJECTIVE: Depression is the most prevalent comorbid psychiatric disease among 
      hemodialysis patients with end-stage renal disease. This cross-sectional study 
      investigated whether depression in hemodialysis patients is associated with the 
      polymorphism of the 5' flanking transcriptional region (5-HTTLPR) of the 
      serotonin transporter gene, the valine (Val)-to-methionine (Met) substitution at 
      codon 66 (Val66Met) polymorphism of the brain-derived neurotrophic factor (BDNF) 
      gene, or plasma BDNF levels. METHODS: A total of 188 participants (mean age: 
      58.5+/-14.0 years; 89 men and 99 women) receiving hemodialysis at the Chang Gung 
      Memorial Hospital were recruited. The diagnosis of major depressive disorder 
      (MDD) was confirmed using the Chinese version of the Mini International 
      Neuropsychiatric Interview. The genotypes of 5-HTTLPR and BDNF Val66Met were 
      conducted using polymerase chain reactions plus restriction fragment length 
      polymorphism analysis. The plasma BDNF levels were measured using an 
      enzyme-linked immunosorbent assay kit. RESULTS: Forty-five (23.9%) patients 
      fulfilled the Diagnostic and Statistical Manual of Mental Disorders, Fourth 
      Edition (DSM-IV-TR) criteria for a MDD. There were no significant effects of the 
      5-HTTLPR or BDNF Val66Met gene polymorphism on MDD among the hemodialysis 
      patients. The plasma BDNF levels correlated significantly with age (P=0.003) and 
      sex (P=0.047) but not with depression, the genotypes of 5-HTTLPR and BDNF 
      Val66Met, the current antidepressant treatment, or the duration under 
      hemodialysis. CONCLUSION: Our results did not support the hypothesis of an 
      involvement of the 5HTTLPR and BDNF Val66Met genotypes, or plasma BDNF levels in 
      the pathogenesis of depression, in patients receiving hemodialysis. A study with 
      a large sample size and homogenous patient group is warranted to confirm these 
      findings.
FAU - Wang, Liang-Jen
AU  - Wang LJ
AD  - Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial 
      Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
FAU - Chen, Chih-Ken
AU  - Chen CK
AD  - Department of Psychiatry, Chang Gung Memorial Hospital, Keelung, Taiwan ; Chang 
      Gung University School of Medicine, Taoyuan, Taiwan.
FAU - Hsu, Heng-Jung
AU  - Hsu HJ
AD  - Chang Gung University School of Medicine, Taoyuan, Taiwan ; Department of 
      Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.
FAU - Wu, I-Wen
AU  - Wu IW
AD  - Chang Gung University School of Medicine, Taoyuan, Taiwan ; Department of 
      Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.
FAU - Sun, Chiao-Yin
AU  - Sun CY
AD  - Chang Gung University School of Medicine, Taoyuan, Taiwan ; Department of 
      Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.
FAU - Lee, Chin-Chan
AU  - Lee CC
AD  - Chang Gung University School of Medicine, Taoyuan, Taiwan ; Department of 
      Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20140705
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC4094571
OTO - NOTNLM
OT  - BDNF
OT  - gene
OT  - hemodialysis
OT  - medical disease
OT  - mood disorder
OT  - serotonin
EDAT- 2014/07/22 06:00
MHDA- 2014/07/22 06:01
PMCR- 2014/07/05
CRDT- 2014/07/22 06:00
PHST- 2014/07/22 06:00 [entrez]
PHST- 2014/07/22 06:00 [pubmed]
PHST- 2014/07/22 06:01 [medline]
PHST- 2014/07/05 00:00 [pmc-release]
AID - ndt-10-1235 [pii]
AID - 10.2147/NDT.S54277 [doi]
PST - epublish
SO  - Neuropsychiatr Dis Treat. 2014 Jul 5;10:1235-41. doi: 10.2147/NDT.S54277. 
      eCollection 2014.