PMID- 25045713
OWN - NLM
STAT- MEDLINE
DCOM- 20150312
LR  - 20211021
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2014
DP  - 2014
TI  - Gradually increased training intensity benefits rehabilitation outcome after 
      stroke by BDNF upregulation and stress suppression.
PG  - 925762
LID - 10.1155/2014/925762 [doi]
LID - 925762
AB  - Physical training is necessary for effective rehabilitation in the early 
      poststroke period. Animal studies commonly use fixed training intensity 
      throughout rehabilitation and without adapting it to the animals' recovered motor 
      ability. This study investigated the correlation between training intensity and 
      rehabilitation efficacy by using a focal ischemic stroke rat model. Eighty male 
      Sprague-Dawley rats were induced with middle cerebral artery 
      occlusion/reperfusion surgery. Sixty rats with successful stroke were then 
      randomly assigned into four groups: control (CG, n = 15), low intensity (LG, n = 
      15), gradually increased intensity (GIG, n = 15), and high intensity (HG, n = 
      15). Behavioral tests were conducted daily to evaluate motor function recovery. 
      Stress level and neural recovery were evaluated via plasma corticosterone and 
      brain-derived neurotrophic factor (BDNF) concentration, respectively. GIG rats 
      significantly (P < 0.05) recovered motor function and produced higher hippocampal 
      BDNF (112.87 +/- 25.18 ng/g). GIG and LG rats exhibited similar stress levels 
      (540.63 +/- 117.40 nM/L and 508.07 +/- 161.30 nM/L, resp.), which were significantly 
      lower (P < 0.05) than that (716.90 +/- 156.48 nM/L) of HG rats. Training with 
      gradually increased intensity achieved better recovery with lower stress. Our 
      observations indicate that a training protocol that includes gradually increasing 
      training intensity should be considered in both animal and clinical studies for 
      better stroke recovery.
FAU - Sun, Jing
AU  - Sun J
AUID- ORCID: 0000-0001-9847-3372
AD  - Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic 
      University, Hong Kong.
FAU - Ke, Zheng
AU  - Ke Z
AD  - Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic 
      University, Hong Kong.
FAU - Yip, Shea Ping
AU  - Yip SP
AUID- ORCID: 0000-0002-2170-8185
AD  - Department of Health Technology and Informatics, The Hong Kong Polytechnic 
      University, Hong Kong.
FAU - Hu, Xiao-ling
AU  - Hu XL
AUID- ORCID: 0000-0003-3188-3005
AD  - Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic 
      University, Hong Kong.
FAU - Zheng, Xiao-xiang
AU  - Zheng XX
AD  - College of Biomedical Engineering and Instrument Science, Zhejiang University, 
      Hangzhou 310027, China.
FAU - Tong, Kai-yu
AU  - Tong KY
AUID- ORCID: 0000-0003-4375-653X
AD  - Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic 
      University, Hong Kong.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140619
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Animals
MH  - Brain Ischemia/metabolism/pathology/*rehabilitation
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disease Models, Animal
MH  - Humans
MH  - Infarction, Middle Cerebral Artery/pathology
MH  - Male
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stress, Physiological
MH  - Stroke/metabolism/pathology
MH  - *Stroke Rehabilitation
MH  - Treatment Outcome
PMC - PMC4090448
EDAT- 2014/07/22 06:00
MHDA- 2015/03/13 06:00
PMCR- 2014/06/19
CRDT- 2014/07/22 06:00
PHST- 2014/02/28 00:00 [received]
PHST- 2014/05/14 00:00 [revised]
PHST- 2014/05/21 00:00 [accepted]
PHST- 2014/07/22 06:00 [entrez]
PHST- 2014/07/22 06:00 [pubmed]
PHST- 2015/03/13 06:00 [medline]
PHST- 2014/06/19 00:00 [pmc-release]
AID - 10.1155/2014/925762 [doi]
PST - ppublish
SO  - Biomed Res Int. 2014;2014:925762. doi: 10.1155/2014/925762. Epub 2014 Jun 19.