PMID- 25047451
OWN - NLM
STAT- MEDLINE
DCOM- 20150407
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 7
DP  - 2014
TI  - Methylenetetrahydrofolate reductase C677T polymorphism and type 2 diabetes 
      mellitus in Chinese population: a meta-analysis of 29 case-control studies.
PG  - e102443
LID - 10.1371/journal.pone.0102443 [doi]
LID - e102443
AB  - BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate 
      metabolism, had significant effects on the homocysteine levels. The common 
      functional MTHFR C677T polymorphism had been extensively researched. Several 
      studies had evaluated the relationship between MTHFR C677T polymorphism and type 
      2 diabetes mellitus (T2DM), but the results were still controversial in the 
      Chinese Han population. This meta-analysis was conducted to evaluate the 
      relationship between MTHFR C677T polymorphism and T2DM in the Chinese Han 
      population. METHODS: We searched the relevant studies in multiple electronic 
      databases, which published up to December 2013. We reviewed and extracted data 
      from all the included studies on the relationship between MTHFR C677T 
      polymorphism and T2DM in the Chinese Han population. The odds ratios (ORs) and 
      their 95% confidence intervals (95%CIs) were used to evaluate the relationship. 
      Fixed-effects and random-effects meta-analysis were used to pool ORs by the 
      heterogeneity. Publication bias and sensitivity analysis were also examined. 
      RESULTS: 29 studies were finally included in our meta-analysis, which contained 
      4656 individuals with T2DM and 2127 healthy controls. There was a significant 
      relationship between MTHFR C677T polymorphism and T2DM under dominant (OR: 1.70, 
      95% CI: 1.42-2.02), recessive (OR: 1.48, 95% CI: 1.21-1.80), homozygous (OR: 
      1.89, 95% CI: 1.47-2.42), heterozygous (OR: 1.58, 95% CI: 1.33-1.87), and 
      additive (OR: 1.46, 95% CI: 1.28-1.68) genetic model in a random-effects model. 
      Subgroup analysis also reached similar results. Sensitivity analysis indicated 
      that the overall result were dependable. CONCLUSIONS: There was a significant 
      relationship between MTHFR C677T polymorphism and T2DM in the Chinese Han 
      population. The results of our meta-analysis suggested that MTHFR 677T allele 
      might be a risk genetic factor of T2DM in the Chinese Han population.
FAU - Zhu, Bo
AU  - Zhu B
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      China Medical University, Shenyang, People's Republic of China; Liaoning Academy 
      of Safety Science, Shenyang, People's Republic of China.
FAU - Wu, Xiaomei
AU  - Wu X
AD  - Department of Clinical Epidemiology and Evidence Medicine, The First Hospital of 
      China Medical University, Shenyang, People's Republic of China.
FAU - Zhi, Xueyuan
AU  - Zhi X
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      China Medical University, Shenyang, People's Republic of China.
FAU - Liu, Lei
AU  - Liu L
AD  - Key Laboratory of Endocrine diseases in Liaoning Province, The First Hospital of 
      China Medical University, Shenyang, People's Republic of China.
FAU - Zheng, Quanmei
AU  - Zheng Q
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      China Medical University, Shenyang, People's Republic of China.
FAU - Sun, Guifan
AU  - Sun G
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      China Medical University, Shenyang, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20140721
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - *Polymorphism, Single Nucleotide
PMC - PMC4105552
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/07/23 06:00
MHDA- 2015/04/08 06:00
PMCR- 2014/07/21
CRDT- 2014/07/23 06:00
PHST- 2013/09/20 00:00 [received]
PHST- 2014/06/19 00:00 [accepted]
PHST- 2014/07/23 06:00 [entrez]
PHST- 2014/07/23 06:00 [pubmed]
PHST- 2015/04/08 06:00 [medline]
PHST- 2014/07/21 00:00 [pmc-release]
AID - PONE-D-13-38813 [pii]
AID - 10.1371/journal.pone.0102443 [doi]
PST - epublish
SO  - PLoS One. 2014 Jul 21;9(7):e102443. doi: 10.1371/journal.pone.0102443. 
      eCollection 2014.