PMID- 25047873
OWN - NLM
STAT- MEDLINE
DCOM- 20150527
LR  - 20140909
IS  - 1532-2785 (Electronic)
IS  - 0143-4179 (Linking)
VI  - 48
IP  - 5
DP  - 2014 Oct
TI  - Neonatal manipulation of oxytocin prevents lipopolysaccharide-induced decrease in 
      gene expression of growth factors in two developmental stages of the female rat.
PG  - 281-6
LID - S0143-4179(14)00064-X [pii]
LID - 10.1016/j.npep.2014.06.004 [doi]
AB  - Oxytocin production and secretion is important for early development of the 
      brain. Long-term consequences of manipulation of oxytocin system might include 
      changes in markers of brain plasticity - cytoskeletal proteins and neurotrophins. 
      The aim of the present study was (1) to determine whether neonatal oxytocin 
      administration affects gene expression of nestin, microtubule-associated 
      protein-2 (MAP-2), brain derived neurotrophic factor (BDNF) and nerve growth 
      factor (NGF) in the brain of two developmental stages of rat and (2) to evaluate 
      whether neonatal oxytocin administration protects against lipopolysaccharide 
      (LPS) induced inflammation. Neonatal oxytocin did not prevent a decrease of body 
      weight in the LPS treated animals. Oxytocin significantly increased gene 
      expression of BDNF in the right hippocampus in 21-day and 2-month old rats of 
      both sexes. Gene expression of NGF and MAP-2 significantly increased in males 
      treated with oxytocin. Both, growth factors and intermediate filament-nestin mRNA 
      levels, were reduced in females exposed to LPS. Oxytocin treatment prevented a 
      decrease in the gene expression of only growth factors. In conclusion, neonatal 
      manipulation of oxytocin has developmental and sex-dependent effect on markers of 
      brain plasticity. These results also indicate, that oxytocin may be protective 
      against inflammation particularly in females.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Bakos, Jan
AU  - Bakos J
AD  - Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, 
      Slovakia; Institute of Physiology, Medical Faculty, Comenius University, 
      Bratislava, Slovakia. Electronic address: j.bakos@savba.sk.
FAU - Lestanova, Zuzana
AU  - Lestanova Z
AD  - Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, 
      Slovakia.
FAU - Strbak, Vladimir
AU  - Strbak V
AD  - Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, 
      Slovakia; Department of Normal and Pathological Physiology, Medical Faculty, 
      Slovak Medical University, Bratislava, Slovakia.
FAU - Havranek, Tomas
AU  - Havranek T
AD  - Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, 
      Slovakia.
FAU - Bacova, Zuzana
AU  - Bacova Z
AD  - Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, 
      Slovakia; Department of Normal and Pathological Physiology, Medical Faculty, 
      Slovak Medical University, Bratislava, Slovakia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140707
PL  - Netherlands
TA  - Neuropeptides
JT  - Neuropeptides
JID - 8103156
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nes protein, rat)
RN  - 0 (Nestin)
RN  - 0 (RNA, Messenger)
RN  - 50-56-6 (Oxytocin)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Encephalitis/chemically induced/*metabolism
MH  - Female
MH  - Gene Expression/*drug effects
MH  - Hippocampus/*drug effects/metabolism
MH  - Lipopolysaccharides
MH  - Male
MH  - Microtubule-Associated Proteins/genetics
MH  - Nerve Growth Factor/genetics
MH  - Nerve Growth Factors/*genetics
MH  - Nerve Tissue Proteins/*genetics
MH  - Nestin/genetics
MH  - Neuronal Plasticity
MH  - Oxytocin/*pharmacology
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Development
OT  - MAP-2
OT  - Nestin
OT  - Neurotrophic factors
OT  - Oxytocin
EDAT- 2014/07/23 06:00
MHDA- 2015/05/28 06:00
CRDT- 2014/07/23 06:00
PHST- 2013/12/06 00:00 [received]
PHST- 2014/06/20 00:00 [revised]
PHST- 2014/06/30 00:00 [accepted]
PHST- 2014/07/23 06:00 [entrez]
PHST- 2014/07/23 06:00 [pubmed]
PHST- 2015/05/28 06:00 [medline]
AID - S0143-4179(14)00064-X [pii]
AID - 10.1016/j.npep.2014.06.004 [doi]
PST - ppublish
SO  - Neuropeptides. 2014 Oct;48(5):281-6. doi: 10.1016/j.npep.2014.06.004. Epub 2014 
      Jul 7.