PMID- 25048132
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20211021
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 1184
DP  - 2014
TI  - Classification of human leukocyte antigen (HLA) supertypes.
PG  - 309-17
LID - 10.1007/978-1-4939-1115-8_17 [doi]
AB  - Identification of new antigenic peptides, derived from infectious agents or 
      cancer cells, which bind to human leukocyte antigen (HLA) class I and II 
      molecules, is of importance for the development of new effective vaccines capable 
      of activating the cellular arm of the immune response. However, the barrier to 
      the development of peptide-based vaccines with maximum population coverage is 
      that the restricting HLA genes are extremely polymorphic resulting in a vast 
      diversity of peptide-binding HLA specificities and a low population coverage for 
      any given peptide-HLA specificity. One way to reduce this complexity is to group 
      thousands of different HLA molecules into several so-called HLA supertypes: a 
      classification that refers to a group of HLA alleles with largely overlapping 
      peptide binding specificities. In this chapter, we focus on the state-of-the-art 
      classification of HLA supertypes including HLA-I supertypes and HLA-II supertypes 
      and their application in development of peptide-based vaccines.
FAU - Wang, Mingjun
AU  - Wang M
AD  - Center for Inflammation and Epigenetics, Houston Methodist Research Institute, 
      6670 Bertner Street, Houston, TX, 77030, USA, mwang429@gmail.com.
FAU - Claesson, Mogens H
AU  - Claesson MH
LA  - eng
GR  - HHSN266200400025C/PHS HHS/United States
GR  - HHSN266200400081C/PHS HHS/United States
GR  - HHSN266200400083C/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Peptides)
RN  - 0 (Vaccines)
SB  - IM
MH  - Histocompatibility Antigens Class I/*classification/immunology
MH  - Histocompatibility Antigens Class II/*classification/immunology
MH  - Humans
MH  - Peptides/*immunology
MH  - Vaccines/*immunology
PMC - PMC7121184
EDAT- 2014/07/23 06:00
MHDA- 2015/03/31 06:00
PMCR- 2020/04/03
CRDT- 2014/07/23 06:00
PHST- 2014/07/23 06:00 [entrez]
PHST- 2014/07/23 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2020/04/03 00:00 [pmc-release]
AID - 17 [pii]
AID - 10.1007/978-1-4939-1115-8_17 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2014;1184:309-17. doi: 10.1007/978-1-4939-1115-8_17.