PMID- 25049154
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140725
LR  - 20140722
IS  - 1572-1000 (Print)
IS  - 1572-1000 (Linking)
VI  - 3
IP  - 3
DP  - 2006 Sep
TI  - Influence of formulation factors on methyl-ALA-induced protoporphyrin IX 
      accumulation in vivo.
PG  - 190-201
LID - 10.1016/j.pdpdt.2006.03.007 [doi]
AB  - Photodynamic therapy (PDT) is a medical treatment by which a combination of a 
      photosensitising drug and visible light cause the destruction of selected cells. 
      Thick lesions, such as nodular basal cell carcinomas (BCCs), or lesions with 
      overlying keratinous debris, are reported as being difficult to eradicate using 
      5-aminolevulinic acid-based photodynamic therapy (ALA-PDT). Such treatment 
      failures have been attributed to the shallow penetration of water-soluble drugs 
      like ALA. In addition, the current scarcity of sophisticated drug delivery 
      research centered on PDT applications has meant that accurate comparison of 
      similar clinical studies is difficult. This paper investigates, for the first 
      time, novel drug delivery systems for controlled drug delivery of methyl-ALA 
      (M-ALA). Pressure sensitive adhesive (PSA) and bioadhesive patches containing 
      defined M-ALA loadings and a standard cream containing equivalent amounts of drug 
      were applied to the skin of mice for defined periods of time and the fluorescence 
      of the protoporphyrin IX (PpIX) induced measured over 24h. Of major importance, 
      the PSA patches containing low drug loadings induced high PpIX levels, which were 
      limited to the site of application, after only 1h applications. Such systems have 
      the potential to improve selectivity of PpIX accumulation, increase simplicity of 
      treatment and, due to the low drug loadings required, reduce costs of clinical 
      PDT. PSA patches would be most suitable for application to areas of dry skin, 
      while bioadhesive patches would be suitable for moist areas, such as the mouth or 
      lower female reproductive tract and have been shown here to induce significant 
      PpIX production at the site of application after 4h applications of patches 
      containing high drug loadings.
FAU - Donnelly, Ryan F
AU  - Donnelly RF
AD  - School of Pharmacy, Queens University Belfast, Medical Biology Centre, 97 Lisburn 
      Road, Belfast BT9 7BL, UK; Department of Radiation Biology, Institute for Cancer 
      Research, The Norwegian Radium Hospital, Montebello 0310, Oslo, Norway.
FAU - Juzenas, Petras
AU  - Juzenas P
AD  - Department of Radiation Biology, Institute for Cancer Research, The Norwegian 
      Radium Hospital, Montebello 0310, Oslo, Norway; Fellow of the Norwegian Cancer 
      Society, P.O. Box 4 Sentrum 0101, Oslo, Norway.
FAU - McCarron, Paul A
AU  - McCarron PA
AD  - School of Pharmacy, Queens University Belfast, Medical Biology Centre, 97 Lisburn 
      Road, Belfast BT9 7BL, UK.
FAU - Ma, Li-Wei
AU  - Ma LW
AD  - Department of Radiation Biology, Institute for Cancer Research, The Norwegian 
      Radium Hospital, Montebello 0310, Oslo, Norway.
FAU - Woolfson, A David
AU  - Woolfson AD
AD  - School of Pharmacy, Queens University Belfast, Medical Biology Centre, 97 Lisburn 
      Road, Belfast BT9 7BL, UK.
FAU - Moan, Johan
AU  - Moan J
AD  - Department of Radiation Biology, Institute for Cancer Research, The Norwegian 
      Radium Hospital, Montebello 0310, Oslo, Norway; Institute of Physics, University 
      of Oslo, P.O. Box 1048 Blindern 0316, Oslo, Norway.
LA  - eng
PT  - Journal Article
DEP - 20060503
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
EDAT- 2006/09/01 00:00
MHDA- 2006/09/01 00:01
CRDT- 2014/07/23 06:00
PHST- 2006/01/18 00:00 [received]
PHST- 2006/03/09 00:00 [revised]
PHST- 2006/03/13 00:00 [accepted]
PHST- 2014/07/23 06:00 [entrez]
PHST- 2006/09/01 00:00 [pubmed]
PHST- 2006/09/01 00:01 [medline]
AID - S1572-1000(06)00056-1 [pii]
AID - 10.1016/j.pdpdt.2006.03.007 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2006 Sep;3(3):190-201. doi: 
      10.1016/j.pdpdt.2006.03.007. Epub 2006 May 3.