PMID- 25050075
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140722
LR  - 20211021
IS  - 1178-7090 (Print)
IS  - 1178-7090 (Electronic)
IS  - 1178-7090 (Linking)
VI  - 7
DP  - 2014
TI  - Up-regulation of brain-derived neurotrophic factor in the dorsal root ganglion of 
      the rat bone cancer pain model.
PG  - 415-23
LID - 10.2147/JPR.S63527 [doi]
AB  - Metastatic bone cancer causes severe pain, but current treatments often provide 
      insufficient pain relief. One of the reasons is that mechanisms underlying bone 
      cancer pain are not solved completely. Our previous studies have shown that 
      brain-derived neurotrophic factor (BDNF), known as a member of the neurotrophic 
      family, is an important molecule in the pathological pain state in some pain 
      models. We hypothesized that expression changes of BDNF may be one of the factors 
      related to bone cancer pain; in this study, we investigated changes of BDNF 
      expression in dorsal root ganglia in a rat bone cancer pain model. As we 
      expected, BDNF mRNA (messenger ribonucleic acid) and protein were significantly 
      increased in L3 dorsal root ganglia after intra-tibial inoculation of MRMT-1 rat 
      breast cancer cells. Among the eleven splice-variants of BDNF mRNA, exon 1-9 
      variant increased predominantly. Interestingly, the up-regulation of BDNF is 
      localized in small neurons (mostly nociceptive neurons) but not in medium or 
      large neurons (non-nociceptive neurons). Further, expression of nerve growth 
      factor (NGF), which is known as a specific promoter of BDNF exon 1-9 variant, was 
      significantly increased in tibial bone marrow. Our findings suggest that BDNF is 
      a key molecule in bone cancer pain, and NGF-BDNF cascade possibly develops bone 
      cancer pain.
FAU - Tomotsuka, Naoto
AU  - Tomotsuka N
AD  - Department of Anesthesiology and Resuscitology, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Kaku, Ryuji
AU  - Kaku R
AD  - Department of Anesthesiology and Resuscitology, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Obata, Norihiko
AU  - Obata N
AD  - Department of Anesthesiology and Resuscitology, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Matsuoka, Yoshikazu
AU  - Matsuoka Y
AD  - Department of Anesthesiology and Resuscitology, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Kanzaki, Hirotaka
AU  - Kanzaki H
AD  - Department of Pharmacy, Okayama University Hospital, Okayama, Japan.
FAU - Taniguchi, Arata
AU  - Taniguchi A
AD  - Department of Anesthesiology and Resuscitology, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Muto, Noriko
AU  - Muto N
AD  - Department of Anesthesiology and Resuscitology, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Omiya, Hiroki
AU  - Omiya H
AD  - Department of Anesthesiology and Resuscitology, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Itano, Yoshitaro
AU  - Itano Y
AD  - Department of Anesthesiology and Resuscitology, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Sato, Tadasu
AU  - Sato T
AD  - Department of Oral and Craniofacial Anatomy, Tohoku University Graduate School of 
      Dentistry, Sendai, Japan.
FAU - Ichikawa, Hiroyuki
AU  - Ichikawa H
AD  - Department of Oral and Craniofacial Anatomy, Tohoku University Graduate School of 
      Dentistry, Sendai, Japan.
FAU - Mizobuchi, Satoshi
AU  - Mizobuchi S
AD  - Department of Anesthesiology and Resuscitology, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Morimatsu, Hiroshi
AU  - Morimatsu H
AD  - Department of Anesthesiology and Resuscitology, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
LA  - eng
PT  - Journal Article
DEP - 20140711
PL  - New Zealand
TA  - J Pain Res
JT  - Journal of pain research
JID - 101540514
PMC - PMC4103927
OTO - NOTNLM
OT  - BDNF
OT  - bone cancer pain
OT  - chronic pain
OT  - nerve growth factor
EDAT- 2014/07/23 06:00
MHDA- 2014/07/23 06:01
PMCR- 2014/07/11
CRDT- 2014/07/23 06:00
PHST- 2014/07/23 06:00 [entrez]
PHST- 2014/07/23 06:00 [pubmed]
PHST- 2014/07/23 06:01 [medline]
PHST- 2014/07/11 00:00 [pmc-release]
AID - jpr-7-415 [pii]
AID - 10.2147/JPR.S63527 [doi]
PST - epublish
SO  - J Pain Res. 2014 Jul 11;7:415-23. doi: 10.2147/JPR.S63527. eCollection 2014.