PMID- 25050816
OWN - NLM
STAT- MEDLINE
DCOM- 20150331
LR  - 20191210
IS  - 1473-5849 (Electronic)
IS  - 0955-8810 (Linking)
VI  - 25
IP  - 5-6
DP  - 2014 Sep
TI  - Effects of acute social stress on the conditioned place preference induced by 
      MDMA in adolescent and adult mice.
PG  - 532-46
LID - 10.1097/FBP.0000000000000065 [doi]
AB  - Exposure to social defeat stress increases the rewarding effects of 
      psychostimulants in animal models, but its effect on 
      3,4-methylenedioxymethylamphetamine (MDMA) reward has received little attention. 
      In the present study, we evaluated the influence of social defeat on the 
      rewarding effects of MDMA in adolescent [postnatal day (PND) 29-40] and adult 
      (PND 50-61) male mice using the conditioned place preference paradigm. 
      Experimental mice were exposed to social defeat in an agonistic encounter before 
      each session of conditioning with 1.25 or 10 mg/kg of MDMA. The effects of social 
      defeat on corticosterone levels and the motor or the anxiogenic effects of MDMA 
      were also evaluated. Mice exposed to social defeat during adulthood did not show 
      conditioned place preference after conditioning with either dose of MDMA. 
      Conversely, social defeat did not affect the anxiogenic and motor effects of 
      MDMA. Adult mice exposed to social defeat showed higher levels of corticosterone 
      than their controls and adolescent mice. Social stress did not induce behavioural 
      effects in adolescent mice. Our results show that stress induced by social defeat 
      decreases the sensitivity of adult mice to the rewarding effects of MDMA.
FAU - Garcia-Pardo, Maria P
AU  - Garcia-Pardo MP
AD  - Unit of Research Psychobiology of Drug Dependence, Department of Psychobiology, 
      School of Psychology, University of Valencia, Valencia, Spain.
FAU - Rodriguez-Arias, Marta
AU  - Rodriguez-Arias M
FAU - Maldonado, Concepcion
AU  - Maldonado C
FAU - Manzanedo, Carmen
AU  - Manzanedo C
FAU - Minarro, Jose
AU  - Minarro J
FAU - Aguilar, Maria A
AU  - Aguilar MA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Behav Pharmacol
JT  - Behavioural pharmacology
JID - 9013016
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Aging/drug effects/physiology
MH  - Animals
MH  - Anxiety/chemically induced/physiopathology
MH  - *Conditioning, Psychological
MH  - Corticosterone/metabolism
MH  - Dominance-Subordination
MH  - Dose-Response Relationship, Drug
MH  - Hallucinogens/*pharmacology
MH  - Male
MH  - Mice
MH  - Motor Activity/drug effects/physiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Reward
MH  - *Social Behavior
MH  - Space Perception/*drug effects/physiology
MH  - Stress, Psychological/*physiopathology
EDAT- 2014/07/23 06:00
MHDA- 2015/04/01 06:00
CRDT- 2014/07/23 06:00
PHST- 2014/07/23 06:00 [entrez]
PHST- 2014/07/23 06:00 [pubmed]
PHST- 2015/04/01 06:00 [medline]
AID - 10.1097/FBP.0000000000000065 [doi]
PST - ppublish
SO  - Behav Pharmacol. 2014 Sep;25(5-6):532-46. doi: 10.1097/FBP.0000000000000065.