PMID- 25051275
OWN - NLM
STAT- MEDLINE
DCOM- 20150129
LR  - 20141111
IS  - 2191-0251 (Electronic)
IS  - 0334-018X (Linking)
VI  - 27
IP  - 11-12
DP  - 2014 Nov
TI  - Two case reports of severe pediatric hyperosmolar hyperglycemia and diabetic 
      ketoacidosis accompanied with rhabdomyolysis and acute renal failure.
PG  - 1227-31
LID - 10.1515/jpem-2014-0131 [doi]
AB  - OBJECTIVE: This report describes two adolescent males in China who suffered from 
      type 2 diabetes mellitus (T2DM) and hyperglycemic hyperosmolar syndrome (HHS) 
      complicated by rhabdomyolysis (RM). After sufficient fluid administration, both 
      patients recovered. DESIGN: Case report. RESULTS: These two obese patients 
      suffered from T2DM, DKA and HHS. Because of insufficient fluid administration, 
      these patients became aggravated and suffered from RM. After aggressive fluid 
      resuscitation and insulin injection, the conditions of the two patients improved. 
      Insulin administration was ceased after approximately 1 month of subcutaneous 
      injections. The two patients attained good glucose control with diet management. 
      CONCLUSIONS: HHS is one of the most severe complications of T2DM. RM is a sign 
      that the condition of a patient with HHS may worsen. Although management 
      strategies are undefined, effective fluid infusion was shown to be helpful. Thus, 
      the early signs of HHS and RM should be recognized so as to avoid severe 
      complications.
FAU - Li, Wenjing
AU  - Li W
FAU - Gong, Chunxiu
AU  - Gong C
FAU - Wu, Di
AU  - Wu D
FAU - Liu, Min
AU  - Liu M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - J Pediatr Endocrinol Metab
JT  - Journal of pediatric endocrinology & metabolism : JPEM
JID - 9508900
SB  - IM
MH  - Acute Kidney Injury/*etiology/therapy
MH  - Adolescent
MH  - Child
MH  - China
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Ketoacidosis/*complications
MH  - Fluid Therapy
MH  - Humans
MH  - Hyperglycemic Hyperosmolar Nonketotic Coma/*complications
MH  - Male
MH  - Obesity/*physiopathology
MH  - Prognosis
MH  - Rhabdomyolysis/*etiology
MH  - Water-Electrolyte Imbalance
EDAT- 2014/07/23 06:00
MHDA- 2015/01/30 06:00
CRDT- 2014/07/23 06:00
PHST- 2014/03/23 00:00 [received]
PHST- 2014/06/10 00:00 [accepted]
PHST- 2014/07/23 06:00 [entrez]
PHST- 2014/07/23 06:00 [pubmed]
PHST- 2015/01/30 06:00 [medline]
AID - /j/jpem.ahead-of-print/jpem-2014-0131/jpem-2014-0131.xml [pii]
AID - 10.1515/jpem-2014-0131 [doi]
PST - ppublish
SO  - J Pediatr Endocrinol Metab. 2014 Nov;27(11-12):1227-31. doi: 
      10.1515/jpem-2014-0131.